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Table of contents
INTRODUCTION
Chapter I. Literature review
1. Lactic Acid Bacteria
1.1 Lactococcus lactis
1.2 Application of L. lactis for food and health issues
2. Gastrointestinal mucus
2.1 Components, organization and functions
2.2 Rheological properties of GI mucus
2.3 Mucus microrheology and microstructure
3. Interactions between LAB and mucus
3.1 Determinants of the bacterial cell surface involved in adhesion and muco-adhesion
3.2 Adhesion of L. lactis to the intestinal mucosa and mucus: in vitro and in vivo approaches
4. Identification of the natural L. lactis subsp. lactis isolate TIL448: cell surface determinants and adhesive properties to abiotic and biotic surfaces
4.1. Diversity of L. lactis strains in terms of physico-chemical properties
4.2. Specific adhesion of TIL448 to Caco-2 human intestinal epithelial cells
4.3. Identification and functional role of TIL448 surface proteins in adhesion to Caco-2 cells
Chapter II. Objectives of the study
1. Adhesion and migration of L. lactis TIL448 inside PGM-based hydrogels: role of pili and mucus-binding protein
2. Scrutinizing the microstructure of porcine gastric mucins by fluorescence multiple particle tracking and microrheometry
Chapter III. Results
1. Adhesion and migration of L. lactis TIL448 inside PGM-based hydrogels: role of pili and mucus-binding protein
1.1. Unraveling the Role of Surface Mucus-Binding Protein and Pili in Muco-Adhesion of Lactococcus lactis
1.2. Further investigations on the migration ability of L. lactis inside PGM-based hydrogels
2. Scrutinizing the microstructure of porcine gastric mucins by fluorescence multiple particle tracking and microrheometry
Chapter IV. Discussion – General conclusion
APPENDIX. Experimental protocols for DFT measurements
REFERENCES
LIST OF TABLES
LIST OF FIGURES
SUMMARY IN FRENCH
