Bacilliformis and sandflies

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Table of contents

Chapter one Bartonella and its survival in different microenvironments 
1. Analysis of Bartonellae genomes
2. Diseases caused in humans; diagnosis and treatment of Bartonellosis
3. The cycle of Bartonella in the mammalian reservoir host
4. Bartonella and erythrocyte parasitism
5. Bartonella interaction with endothelial cells
6. Bartonellae and their vectors
Chapter two Iron/Heme uptake in Bartonella 
1. Free Fe(II) and its transport
2. Transferrin and lactoferrin iron transport
3. Siderophore and Hemophore
4. Receptors for siderophores and heme/hemophore
5. The TonB-ExbB-ExbD complex
6. Transport across the periplasm and cytoplasmic membrane
7. Fate of the ferri-siderophore and heme in the cytoplasm
8. Regulation of iron and heme uptake in Gram-negative bacteria
9. The heme uptake system in Bartonella
Chapter three Research significance and Purpose of the work 
Results
Paper one Heme degrading protein HemS is involved in oxidative stress response of Bartonella henselae
State of the art concerning the fate of heme in the cytoplasm
Paper two Heme binding proteins of Bartonella henselae are required when undergoing oxidative stress during cell and flea invasion
State of the art concerning outer membrane heme binding proteins of Bartonella
1. Outer membrane heme binding proteins in Gram-negative bacteria
2. The finding of heme binding proteins in Bartonella and their structure
3. Heme binding proteins cannot transport heme
4. Heme binding proteins and interactions with the infected host
5. Regulation of expression of heme binding proteins in Bartonella
Discussion Discussion and perspectives
Supplement Paper Identification of a novel nanoRNase in Bartonella
References References