Oxidative Stress and Inflammation

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Table of contents

Chapter I. General Introduction
I.1 Sickle Cell Disease vs. Atherosclerosis
I.2 Exercise Training
Chapter II: Oxidative Stress and Inflammation
II.1 Oxidative Stress
II.2 Inflammation
II.2a Cytokine Signaling Pathways
II.3 Link between Oxidative Stress & Inflammation
II.4 Effects of Exercise on Oxidative Stress & Inflammation
II.4a Acute Exercise
II.4b Chronic Exercise
II.5 Conclusion
II.6 References
Chapter III: Sickle Cell Disease and Sickle Cell Trait
III.1 Sickle Cell Disease
III.1a Pathogenesis
III.2 Role of Oxidative Stress (Published Review: See Annex IX.1a)
III.2a. Blood Cell Auto-oxidation
III.2b. Sickling & Hemolysis
III.2c. Fate of Nitric Oxide
III.2d RBC Adhesion & Vaso-occlusion
III.2e. Hypoxia/Reperfusion Injury
III.2f Anti-oxidants
III.2g Anti-oxidant therapeutic strategies
III.3 Role of Exercise
III.3a Exercise in SCT
III.3b Exercise in SCD
III.4 References
Chapter IV
IV.1 Introduction to Article #1
IV.2 Exercise training blunts oxidative stress in sickle cell trait carriers
Chapter V Atherosclerosis
V.1 Plaque Development
V.1a Vascular Components: The vessel wall
V.1b Vascular Components: The endothelium
V.2 Pathogenesis of Atherosclerosis
V.3 Generation of oxidative stress and inflammation in Atherosclerosis
V.3a Role of oxidative stress and inflammation in macrophages
V.3b Role of oxidative stress and inflammation on endothelial dysfunction
V.3c Role of oxidative stress and inflammation on adhesion
V.4 Non-invasive methods for plaque vulnerability investigation
V.4a Magnetic Resonance Imaging (MRI)
V.4b Imaging in Atherosclerosis
V.4c Animal models of advanced lesions
V.5 Effects of exercise training in atherosclerosis
V.5a LDL
V.5b Endothelial dysfunction
V.5c Macrophage/leukocyte recruitment
V.5d Adhesion
V.5e Plaque instability
V.6 References
Chapter VI: Article #2
VII. Conclusions and Perspectives
VII.1 Sickle Cell Disease and Trait
VII.1a Conclusion
VII.1b Perspectives
VI.2 Atherosclerosis
VII.2a Conclusion
VII. 2b Perspectives
VII.3 Final Conclusion
VIII. Publications & Communications
VIII.1 Articles related to my published in Peer-reviewed scientific Journals
VIII.2 International Conference Proceedings
IX. Annex
IX.1 Published Papers
IX.1a Role of Oxidative Stress in the Pathogenesis of Sickle Cell Disease
IX.1b Exercise training blunts oxidative stress in sickle cell trait carriers
IX.1c Editorial: Research in Athletes with Sickle Cell Trait: Just Do It
IX.1d Effect of 􀄮–thalassemia on exercise-induced oxidative stress in sickle cell trait
IX.1e In vivo cardiac anatomical and functional effects of wheel running in mice by magnetic resonance imaging
IX.2 Supplemental Research Data (not published)
IX.2a BMDM differentiation