The heterogeneity of fibroblasts

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Table of contents

I. Introduction and objectives
1.4.1. Structure and main components
1.4.2. Dermal vascular, lymphatic and nervous systems
1.4.3. Skin appendages
The dermis: a highly dynamic and complex compartment 
2.1.1. An introduction to the extracellular matrix components: the matrisome
2.1.2. Composition and structure of the dermal interstitial matrix
2.1.3. Remodeling of the ECM
2.2.1. Fibroblasts are heterogeneous and plastic cells
2.2.2. Fibroblast activation and regulation of ECM deposition
2.2.3. The dynamic interplay between dermal fibroblasts, ECM and surrounding cells
2.2.4. Heterogeneity of dermal fibroblasts
3.2.1. History of the central transcription factor, NRF2
3.2.2. NRF2-KEAP1 structures and stress response pathway
3.2.3. NRF2 target genes and main functions
3.2.4. NRF2 additional functions through crosstalk with other signaling pathways.
3.2.5. Regulation of NRF2 activity
4.3.1. NRF2 contributes to the maintenance of the epidermal barrier function
4.3.2. NRF2 activity is associated with skin fibrosis
4.3.3. The dual role of NRF2 in skin cancer
II. Results
1. Part 1 « The transcription factor NRF2 regulates matrisome gene expression and collagen fibrillogenesis in human skin fibroblasts “
Manuscript in preparation
Part 2 “Role of AMPK in dermis”
Additional results
III. General discussion and perspectives
References