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Table of contents
Chapter 1. Introduction
1.1 Nitric oxide
1.2 Nitric oxide and cardiovascular diseases (CVD)
1.2.1 Nitric oxide in the cardiovascular system
1.2.2 NO signaling in vascular beds in health and disease. .
1.3 NO storage
1.4 Nitric oxide donors
1.4.1 Direct Donors
1.4.2 Donors Requiring Metabolism
1.4.3 New NO donors
Article 1: Synthesis of Novel Mono and Bis Nitric Oxide Donors with High Cytocompatibility and Release Activity
The stability and biological chemistry of RSNOs
1.5 GSNO
1.5.1 Chemical Synthesis of GSNO
1.5.2 In vitro stability
1.5.3 In vivo metabolism
1.6 GSNO related delivery systems and therapeutic potentials
1.6.1 Intravenous administration
1.6.2 Topical administration
1.6.3 Implants
1.6.4 Oral administration
1.6.5 Gastrointestinal barrier:
1.7 Nanoparticles/microparticles for oral delivery of biological molecules
1.7.1 Nanoparticles targeting the gastrointestinal tract
1.7.2 Microparticles for oral delivery
Chapter 2: Intestinal permeability of S-nitrosothiols
2.1 Transport mechanism through intestinal barrier
2.2 Intestinal permeability measurement with Caco-2 cell monolayer model
2.3 Biopharmaceutical Classification System
Article 2: Intestinal absorption of S-nitrosothiols: permeability and transport mechanisms
Chapter 3: Vascular NO storage and its vasoactivity
3.1 NO storage
3.2 Endothelial dysfunction
Article 3: S-nitrosothiols as potential therapeutics to induce a mobilizable vascular store of nitric oxide to counteract endothelial dysfunction
Chapter 4: Nano or micro? Three different particles to deliver GSNO through oral route. Eudragit® RL PO
Double emulsion (W/O/W and S/O/W)
Water in oil in water (W/O/W) double emulsion
Solid in oil in water (S/O/W) double emulsion
Article 4: Three different particle types to protect and deliver S-nitrosoglutathione: nanoparticles, water-in-oil-in-water microparticles and solid-in-oil-in-water microparticles
General discussion, conclusions and perspectives
