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Table of contents
Chapter 1. Introduction
1.1 Inflammation bowel disease
1.1.1 IBD epidemiology
1.1.2 IBD physiopathology
1.2 Intestine physiology
1.2.1 Intestinal barrier components
1.2.2 Epithelial passage routes
1.2.3 Intestinal permeability measurement
1.3 IBD therapy
1.3.1 Aminosalicylates
1.3.2 Corticosteroids
1.3.3 Immunosuppressive drugs
1.3.4 Anti-TNF agents
1.3.5 Innovative therapy
1.4 Nitric oxide
1.4.1 Role of nitric oxide in intestinal mucosal defense
1.4.2 NO donors
1.4.3 S-Nitrosoglutathione: a potent S-nitrosothiol
1.5 S-nitrosoglutathione related delivery system
1.5.1 S-nitrosoglutathione conjugated delivery system
1.5.2 S-nitrosation of glutathione related delivery system
1.5.3 Direct S-nitrosoglutathione encapsulation
1.6 Polymer nanocomposites for drug oral delivery: development strategies and potentialities
Chapter 2. Luminal GSNO effects on the intestinal barrier integrity
2.1 Introduction
2.2 Study of the impact of the GSNO on the intestinal barrier permeability
Chapter 3. Formulations of GSNO nanocomposites adapted to oral delivery
3.1 Introduction
3.2 Alginate nanocomposite particles optimization
3.2.1 Pre-optimization
3.2.2 S-nitrosoglutathione loaded alginate nanocomposite particles development
3.2.3 Supplementary study: GSNO alginate nanocomposite particles in vitro release in acidic pH
3.3 Alginate/Eudragit®E 100 nanocomposite particles development
3.3.1 Pre-experiment
3.3.2 Methods
3.3.3 Result and discussion
3.3.4 Conclusion
3.4 Conclusion and perspectives
Chapter 4. General discussion and perspectives
4.1 Discussion
4.1.1 Impact of luminal GSNO on the integrity of the intestinal mucosa
4.1.2 Oral administration of GSNO
