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Table of contents
Chapter 1: General Overview
1. Inorganic/organic core/shell NPs
1.1. Inorganic NPs
1.1.1. ZnO QDs
1.1.2. Iron oxide NPs
1.2. Thermo-responsive polymers
1.2.1. Properties
1.2.2. Oligo (ethylene glycol) methacrylates
1.2.3. Effect of salt on polymer behavior
1.3. Polymerization process of polymer on NPs surface
1.3.1. Grafting methods “grafting from”
1.3.2. Polymerization methods
2. Biological applications of inorganic/organic core/shell NPs
2.1. NPs engineering
2.2. In vitro and in vivo applications
3. Characterization techniques
3.1. High resolution Transmission electron microscopy (HR-TEM)
3.2. Dynamic Light Scattering (DLS)
3.3. X-ray diffraction (XRD)
3.4. Fourier transmission Infrared Spectroscopy (FT-IR)
3.5. Ultraviolet-Visible (UV-Vis) spectroscopy
3.6. Fluorescence spectroscopy
3.7. Thermal Gravimetric Analysis (TGA)
Chapter 2: Efficient synthetic access to thermo-responsive core/shell nanoparticles
1. INTRODUCTION
2. MATERIALS AND METHODS
2.1. Materials
2.2. Synthesis of ZnO QDs coated with the silane derivatives
2.2.1. Synthesis of hydrophobic ZnO@oleate QDs
2.2.2. Silanization of ZnO QDs
2.2.3. Synthesis of ZnO QDs coated with the P(MEO2MAX-OEGMA100-X)
2.2.4. Preparation of Fe3O4 NPs
2.2.5. Silanization of Fe3O4 NPs
2.2.6. Synthesis of Fe3O4 coated with the P(MEO2MAX-OEGMA100-X)
2.2.7. SiO2 NPs
2.3. Characterization Methods
3. RESULTS AND DISCUSSION
3.1. Growth of PS from SiO2@Ph-Cl
3.2. Growth of P(MEO2MAX-OEGMA100-X) from ZnO and Fe3O4@Ph-Cl NPs
3.3. Physical characterization of the core/shell NPs
3.4. Amount of copolymer grafted at the surface of the NPs
3.5. Temperature responsive properties of the core/shell NPs
3.6. Fluorescence properties of the ZnO@copolymer samples
3.7. Magnetic properties of the Fe3O4@copolymers
4. CONCLUSION
Chapter 3: Synthesis, characterization and cytotoxicity of ZnO@P(MEO2MAX-OEGMA100-X) NPs
1. INTRODUCTION
2. MATERIALS AND METHODS
2.1. Materials
2.2. Synthesis of ZnO@P(MEO2MAX-OEGMA100-X) NPs
2.3. Cytotoxicity tests
2.3.1. Cell culture
2.3.2. Adding the NPs
2.3.3. Performing the MTT cell viability test
3. RESULTS AND DISCUSSION
3.1. Characterization of ZnO and ZnO@P(MEO2MAX-OEGMA100-X) NPs
3.1.1. Chemical Characterization
3.1.2. Microstructural Characterization of the core/shell NPs
3.1.3. Amount of the grafted copolymer
3.1.4. Optical properties of the core/shell NPs
3.2. Thermo-responsive behavior of ZnO@P(MEO2MAX-OEGMA100-X) NPs
3.2.1. In water
3.2.2. In physiological media
3.3. Cytotoxicity Tests
3.3.1. Cytotoxicity of ZnO@P(MEO2MAX-OEGMA100-X) NPs
3.3.2. ZnO@P(MEO2MAX-OEGMA100-X) NPs loaded with DOX
4. CONCLUSION
Chapter 4: Thermo-responsive magnetic Fe3O4@P(MEO2MAX-OEGMA100-X) NPs and their applications as drug delivery systems
1. INTRODUCTION
2. MATERIALS AND METHODS
2.1. Materials
2.2. Synthesis process
2.3. Drug release
2.4. Cytotoxicity
2.5. Characterization Methods
3. RESULTS AND DISCUSSION
3.1. Chemical characterization
3.2. Microstructural characterization of the NPs
3.3. Amount of grafted co-polymer
3.4. Magnetic properties
3.5. Thermo-responsive behavior of the core/shell NPs
3.6. Drug release from Fe3O4@P(MEO2MAX-OEGMA100-X) NPs
3.6.1. DOX release
3.6.2. In vitro cytotoxicity study
4. CONCLUSION
REFERENCES
GENERAL CONCLUSION & PERSPECTIVES
