Prognosis of glioma

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Table of contents

Acknowledgements
Table of contents
List of abbreviations
List of figures
List of tables
1 CHAPTER 1
1.1 Overview of central nervous system (CNS) tumours
1.1.1 Histological classification of glioma
1.1.2 Epidemiology of glioma
1.2 Molecular classification of glioma
1.2.1 Molecular model of glioma development
1.3 Clinical and biological aspects of glioma
1.3.1 Glioma origins
1.3.2 Prognosis of glioma
1.3.3 Treatments of glioma
1.4 Genetic architecture of susceptibility to cancer
1.4.1 Overview
1.4.2 Multi-locus/multi-allele hypothesis
1.4.3 More recent models of genetic susceptibility to glioma
1.5 Identification of common low-penetrance allele
1.5.1 Genome-wide association studies
1.5.2 Imputation
1.6 Genetic susceptibility to glioma
1.6.1 Association studies in glioma
1.6.2 Perspectives from glioma GWAS
1.7 Strategies to identify novel glioma susceptibility alleles
1.7.1 GWAS, Imputation and meta-analysis
1.7.2 Next-generation arrays
1.7.3 Functional annotation of risk SNPs
1.8 Study aims and scope of enquiry
2 CHAPTER 2
2.1 Subjects and samples
2.1.2 Germline gliomas cases controls samples
2.1.3 Anaplastic oligodendroglioma matched tumour/normal samples
2.2 Molecular methods
2.2.1 Illumina whole-exome sequencing
2.2.2 Illumina transcriptome sequencing (RNA-seq)
2.2.3 Genotyping
2.3 Statistical and bioinformatics methods
2.3.1 General statistical methods
2.3.2 General Bioinformatics techniques
2.3.3 Methods for genome-wide association studies
2.3.4 Methods for functional analysis of genomic data
2.3.5 Annotation of regulatory elements
2.3.6 Methods for somatic genomic analysis
2.3.7 Plotting tools
2.3.8 Survival analysis
3 CHAPTER 3
4 CHAPTER 4
4.1 Overview and rational
4.2 Methods
4.2.1 Patients, samples and datasets
4.2.2 Statistical analysis
4.3 Results
4.4 Discussion
5 CHAPTER 5
5.1 Overview and rational
5.2 Methods
5.2.1 Patients, samples and datasets
5.2.2 Statistical and bioinformatics analysis
5.3 Results
5.4 Discussion
6 CHAPTER 6
6.1 Glioma inherited predisposition
6.2 Somatic genetic studies of Anaplastic Oligodentroglioma OA
6.3 Overall conclusion
References
APPENDIX 1
APPENDIX 2