Catalysis in confined space

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Table of contents

General Introduction
Chapter I: Bibliography
I.1: Synthesis and applications of hemicryptophane organic cages
I.1.1 Introduction
I.1.2 Synthesis of hemicryptophanes
I.1.3 Enantiopure hemicryptophanes obtained by means of chiral HPLC resolution
I.1.4 Host-guest chemistry
I.1.5 Catalysis in confined space
I.1.6 Conclusions
I.1.7 References
I.2 Chirality transfer in tripodal supramolecular cages Control and transfer of chirality within well-defined tripodal cages
I.2.1 Abstract
I.2.2 Introduction
I.2.3 Propagation of the chirality in tripodal cages
I.2.4 Chiral-sorting in tripodal cages
I.2.5 Control of the host chirality through guest binding
I.2.6 Conclusion and discussion
I.2.7 References
Chapter II: New small tris(2-pyridylmethyl)amine-based hemicryptophane for predictable control of the ligand’s helicity by chirality transfer
II.1 Chirality Transfer in a Cage Controls the Clockwise / Anticlockwise Propeller-like Arrangement of the tris(2 pyridylmethyl)amine Ligand
II.2 Annex N°1:
II.3 Preliminar catalytic tests on copper-catalyzed asymmetric transformations using enantiopure 1 CuI(Cl) catalyst
II.4 Computational calculations: explanation of the chirality transfer and molecular dynamic of cage
II.4.1 Computational details:
II.4.2 Chirality transfer (issue 1):
II.4.3 Dynamic Aspects (issue 2) :
II.5 Conclusions
II.6 Reference
Chapter III: Design, preparation, and applications of novel tris-triazole based hemicryptophanes
III.1 Introduction
III.1.1 Site selective and enantioselective CuAAC reaction.
III.1.2 Construction of rotaxane and cages by mean of CuAAC reaction
III.2 Result and discussion
III.2.1 Synthesis
III.2.2 CuAAC in confined space : first catalytic tests
III.3 Conclusions
III.4 References
Chapter IV: Design and preparation of a novel hemicryptophane cage with two different metal binding-site
IV.1 Introduction
IV.2 Result and discussion
IV.2.1 Synthesis and characterization of cage
IV.2.2 Preparation and 1H-NMR characterisation of the corresponding diamagnetic Zinc complex.
IV.2.3. Solid states studies
IV.2.4 Study of the interaction of CuII(cage 4)(OTf)2 with N3.
IV.3 Conclusion and perspectives
IV.4 References
Chapter V: Synthesis of CTV-based self-assembled supramolecular cages
V.1 Introduction
V.2 Result and discussion
V.2.1 Synthesis and characterization of pyridine-based CTV ligands
V.2.2 First self-assembly results (group of M. Hardie)
V.3 Conclusions
V.4 References
General conclusions and perspectives