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Table of contents
1. Introduction
1.1. Clinical cardiac imaging: today’s challenges
1.1.1. Major public health issues and common pathologies
1.1.2. Cardiac imaging: purpose and techniques
1.1.2.1. Diagnosis
1.1.2.2. Prognosis
1.1.3. Techniques: advantages and limitations
1.2. Heart physiology
1.2.1. Introduction
1.2.2. Role of the heart
1.2.3. Macroscopic heart anatomy
1.2.4. The cardiac cycle
1.2.5. The myocardium microstructure
1.2.6. The coronary flow mechanics (Rossi 2007)
1.2.7. The myocardium global architecture
1.3. MRI
1.3.1. NMR principles
1.3.2. NMR experiment
1.3.2. MRI techniques: signal formation
1.3.3. MRI: Encoding spatial information
1.3.4. MRI hardware
1.4. Diffusion Weighted Magnetic Resonance Imaging (DW-MRI or DWI)
1.4.1. Diffusion theory
1.4.2. Diffusion encoding
1.4.3. Diffusion computation
1.4.4. DWI contrast and applications
1.4.5. DWI limitations
2. In vivo cardiac DWI: feasibility and development
2.4. In vivo C-DWI: limitations
2.5. In vivo C-DWI: previous achievements
2.5.1. Stimulated-echo approach
2.5.2. Spin-echo approach
2.6. In vivo C-DWI feasibility: analysis in a specified context
2.6.1. Tackling motion: slice thickness theoretical study
2.6.2. Cardiac motion model: Translation Model
2.6.3. Cardiac motion model: Rotation twist Model
2.6.4. Influence of slice thickness: experimental findings
2.6.5. Evolution of signal intensity with repetitions
2.6.6. Delineation of optimal time-window for cardiac DWI triggering
2.7. TMIP-DWI: a new approach to reduce DWI physiological motion sensitivity
2.7.1. Acquisition Method
2.7.2. Non-rigid Registration
2.7.3. TMIP initial results with home-made sequences
2.7.3.1. Spin-echo EPI sequence
2.7.3.2. Diffusion-preparation b-SSFP-DWI sequence
2.7.4. TMIP initial results with product sequence
2.8. PCA-TMIP-DWI: improving robustness and accuracy
2.8.1. PCA filtering
2.8.1.1. Image processing theory
2.8.1.2. PCA optimization
2.8.1.3. PCA experimental results
2.8.2. PCATMIP
2.8.2.1. Theoretical study of TMIP and PCATMIP on DWI images and parameters
2.8.2.2. In vivo results
2.8.2.3. Initial patients’ results
2.8.2.4. Discussion
2.8.2.5. Limitations
3. Conclusions and Outlooks
3.1. Conclusions and discussions
3.2. Perspectives
References
