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Table of contents
1 Photonic approaches to detect single molecule fluorescence at physiological concentration
1.1 Introduction: Single molecule fluorescence spectroscopy
1.2 Improving singlemolecule fluorescence detection
1.2.1 Methods by structuring the laser excitation beam
1.2.2 Methods using photonic structures
1.3 Plasmonic Nanoapertures: ZeroModeWaveguides (ZMWs)
1.4 Overview of plasmonic antennas under research
1.5 Conclusion
2 Light matter interaction at nanoscale
2.1 Optical properties of bulkmetals
2.1.1 Dielectric functions of free electron metals
2.1.2 Interband transitions
2.1.3 Skin depth of metals
2.2 Localized surface plasmon polariton
2.3 Optical antennas
2.3.1 Field enhancement
2.3.2 Decay rates emission close to a nanoantenna
2.3.3 Optical antenna design rules
2.4 Applications of optical antennas
3 Experimental techniques
3.1 Fluorescence Correlation Spectroscopy (FCS)
3.2 Time Correlated Single Photon counting (TCSPC)
3.2.1 Experimental Realization
3.3 Fluorescence characterization procedure in the vicinity of nanoantenna
3.4 Low quantumyield effect
4 NanoAntenna-in-box design to enhance single molecule fluorescence detection
4.1 Fabrication of Nanoantenna-in-box
4.2 Numerical Simulations
4.3 Experimental Setup andMethodology
4.4 Experimental Results
4.5 Applications of Nanoantenna-in-box
4.6 Conclusion
5 Self Assembly of gold nanoparticles for enhanced single molecule detection 69
5.1 Individual Gold nanoparticles
5.1.1 Materials andMethods
5.1.2 FCS analysis in the near-field of a single metal nanoparticle
5.1.3 Results and Discussion
5.2 Gold nano-dimers and trimers
5.2.1 Sample Preparation
5.2.2 Numerical simulation and spectral analysis
5.2.3 FCS analysis in the near field of gold nano-dimers and trimers
5.2.4 Results and Discussion
5.3 Conclusion
Conclusion
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