Immune Responses to Chronic LCMV infection

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Table of contents

ACKNOWLEDGEMENTS
ABREVIATIONS
RESUME EN FRANÇAIS
ABSTRACT
LIST OF FIGURES
I. INTRODUCTION
A. Type I interferons
Type I IFN production
Type IFN signaling
B. Effects of Type I IFNs on Cells of the Immune System
Effects of type I IFNs on CD4+ T cells
Effects of type I IFN on effector and memory CD8+ T cells
C. Effects of Type I IFNs on T Regulatory T Cells (Treg)
D. Type I IFNs and Lymphocytic Choriomeningitis Virus (LCMV) Infection
Immune Responses to Acute LCMV infection
Immune Responses to Chronic LCMV infection
The Role of type I IFN During LCMV infection
Role of Tregs in LCMV infection
E. Type I IFNs in Multiple Sclerosis (MS) and Experimental Autoimmune Encephalomyelitis (EAE)
Multiple Sclerosis (MS)
Tregs in MS
Experimental Autoimmune Encephalomyelitis (EAE)
Tregs in EAE
Role of Type I IFNs in MS/EAE
II. MATERIALS AND METHODS
III. EXPERIMENTAL RESULTS
IV. FIGURES
V. DISCUSSION
REFERENCES