Spinal cord atrophy quantification from MR images

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Table of contents

Contents
Remerciements
List of Tables
List of Figures
Glossary
Abstract
Publications
Articles arising from this work
Additional contributions
1. Introduction
2. Background
Motor neuron diseases
Historical setting
Amyotrophic lateral sclerosis
Spinal muscular atrophy
Spinal cord MRI
Principals of MRI
Challenges
Clinical setting
Research setting
Advanced MRI
3. Objectives
4. Results
Methodological studies
Study 1 – Validation of a semi-automated spinal cord segmentation method
Study 2 – Fast and accurate semi-automated segmentation method of spinal cord MR images at 3T applied to the construction of a cervical spinal cord template
Multi-parametric MRI studies in MND
Study 3 – Electrophysiological and spinal imaging evidence for sensory dysfunction in amyotrophic lateral sclerosis
Study 4 – Multi-parametric spinal cord MRI as potential progression marker in amyotrophic lateral sclerosis
Study 5 – Cervical spinal cord atrophy profile in adult SMN1-linked SMA
5. Discussion
Methodological developments
Multi-parametric MRI studies in MND
Perspectives
Annex A
Annex B
References