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Table of contents
Abstract
Résumé
Table of Contents
Abbreviations
List of Illustrations
1. Introduction
1.1 Epstein-Barr virus
1.1.1 Discovery of Epstein-Barr virus
1.1.2 Classification of EBV
1.1.3 Structure of EBV virion and genome
1.2 EBV infection
1.2.1 Transmission
1.2.2 Primary infection and viral persistence
1.2.3 Viral entry
1.2.4 Immune response
1.3 Life cycle of EBV
1.3.1 Latency
1.3.2 Lytic cycle
1.3.3 Reactivation
1.4 EBV-associated human diseases
1.4.1 Infectious mononucleosis
1.4.2 X‑linked lymphoproliferative disease
1.4.3 Post-transplant lymphoproliferative disease
1.4.4 Burkitt’s lymphoma
1.4.5 Hodgkin’s lymphoma
1.4.6 NK/T-cell lymphoma
1.4.7 Nasopharyngeal carcinoma
1.4.8 Gastric carcinoma
1.5 EBV viral Bcl-2 homologs
1.5.1 Bcl-2 family proteins and viral Bcl-2 homologs
1.5.2 Herpesvirus-encoded Bcl-2 homologs
1.5.3 EBV vBcl-2s
1.6 BHRF1
1.6.1 Expression
1.6.2 Subcellular localization
1.6.3 Function
1.7 BAL0/1
1.7.1 Expression
1.7.2 Subcellular localization
1.7.3 Function
1.8 Autophagy
1.8.1 Different types of autophagy
1.8.2 A multistage process
1.8.3 The autophagic machinery and its regulation pathways
1.8.4 Physiological and pathological roles of autophagy
1.8.5 Selective autophagy
1.9 EBV and autophagy
1.9.1 Autophagy and EBV latency
1.9.2 Autophagy modulation during EBV lytic cycle
1.10 Herpesvirus and autophagy: a lesson to explore the contribution of autophagy to EBV infection
1.10.1 Subversion of autophagy by Herpesviruses
1.10.2 Herpesvirus-encoded vBcl-2s inhibit autophagy
1.11 Aims and objectives
2. Results
2.1 Detection of IgG directed against a recombinant form of Epstein-Barr virus BALF0/1 protein in patients with nasopharyngeal carcinoma
2.2 Epstein-Barr virus BALF0 and BALF1 modulate autophagy
2.3 BHRF1, a Bcl-2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction
3. Discussion
3.1 The existence of EBV BAFL0 and BALF1 in vivo
3.2 EBV vBcl-2s modulate autophagy VI
3.3 The interplay between vBcl-2s of EBV
4. Take home message
5. References
