Predictive biomarkers in the natural course of HIV infection

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Table of contents

I. RESUME DES TRAVAUX DE THESE
II. SCIENTIFIC PRODUCTION
III. ABBREVIATIONS LIST
IV. INTRODUCTION
V. STATE OF THE ART
A. Human immunodeficiency virus (HIV)
1. Epidemiology of HIV infection
2. HIV replication cycle
3. Immune response against HIV infection
4. The natural course of HIV-1 infection
5. Predictive biomarkers in the natural course of HIV infection
B. Highly active antiretroviral therapy: the revolution
1. Classes of antiretroviral therapy
2. Recommendations for first-line cART initiation
3. Benefits of antiretroviral therapy (ART)
4. Complications of cART
C. Beyond cART: failure of eradication, residual viremia and persistent immune activation and inflammation
1. HIV reservoirs and failure of eradication
2. Residual viremia
3. Persistent immune activation and inflammation among HIV-infected patients
VI. MATERIALS AND METHODS
A. Hypothesis and objectives of the study
1. Hypothesis
2. Objectives
B. Study design
1. Inclusion criteria of patients
2. Non-inclusion criteria
3. Controls
4. Ethical aspects
C. Database resources
1. Department of infectious diseases/ Pitié-Salpétrière hospital
2. NADIS®
D. Patients selection, clinical data collection and exportation
E. Plasma collection and preparation
F. Biomarkers selection and measurement
1. Enzyme-Linked ImmunoSorbent Assay (ELISA)
2. Cytometric Bead Array (CBA)
G. Statistical analyses
1. Relationships between biomarker levels and patients characteristics at cART initiation
2. Changes in biomarker levels after two years of effective cART
3. Factors associated with persistent elevated marker levels after 2 years of cART
4. Comparative impact of different ART components on the evolution of biomarkers
5. Sensitivity analyses
VII. RESULTS
A. Impact of two years of effective first-line cART on soluble biomarkers of immune activation and inflammation
1. Summary of the study
2. Submitted article 1
3. Supplementary data
B. Comparative impact of different ART components on the evolution of immune activation and inflammation markers
1. Summary of the study
2. Published article 2
3. Supplementary data
VIII. DISCUSSION
IX. CONCLUSIONS AND PERSPECTIVES
X. BIBLIOGRAPHY