GABAB receptor regulation

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Table of contents

I. A brief history of depression
II. Treatment of major depressive disorder
III. Studying depression in laboratory animals
A. Learned helplessness model
B. The chronic mild stress
C. Social defeat
D. Maternal separation
Neural circuits of depression
Emerging role of LHb in depression
I. Lateral habenula as a node to control midbrain regions
II. Lateral habenula function in processing negative information
III. Lateral habenula modifications in depression
I. GABAB receptor structure and function
II. GABA B receptors trafficking
III. GABAB receptor regulation
Methodological section
Experimental subjects and stress paradigms
Behavioral tests
Drug/intervention
Surgery
Electrophysiology
Analysis and drugs.
I. Stress-driven mechanisms underlying GABAB receptor plasticity in the LHb
II. Induction mechanism of GABAB receptor plasticity following different kind of stress
III. Circuit specificity of GABAB receptor regulation in the LHb
IV. What is the functional relevance of GABAB receptor dependent hyperexcitability for the emergence of depressive like symptoms
V. Targeting LHb hyperexcitability to treat depression?
A. Caveat of DBS intervention:
B. PP2A inhibitors as potential antidepressant drugs
C. Consequences of LHb hyperexcitability on downstream circuitries
Conclusion