Oncolytic peptide LTX-401

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Table of contents

INTRODUCTION
Cancer and anticancer immunity
Cancer epidemiology
Cancer immunology
Immunogenic cell death in cancer therapy
Major DAMPs of ICD
Methods to detect ICD
ICD inducers
Induction of ICD sensitize cancers to immune checkpoint blockade
Transcription inhibitor Lurbinectedin
Oncolytic peptide LTX-401
AIMS OF THE THESIS
RESULTS
Lurbinectedin synergizes with immune checkpoint blockade to generate
anticancer immunity
Tumor lysis with LTX-401 creates anticancer immunity
CONCLUDING REMARKS
ACKNOWLEDGEMENT
REFERENCES
ANNEX 1: SCIENTIFIC PUBLICATIONS
ANNEX 2: PAPERS NOT INCLUDED IN THIS THESIS (INSERTED IN PDF)