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Table of contents
I Introduction
1 The presubiculum: Anatomy, function, microcircuit
1.1 The presubicular cortex
1.1.1 Anatomy
1.1.2 What kind of cortex?
1.2 Presubiculum and spatial orientation
1.2.1 Head direction cells of the presubiculum
1.2.2 Head Direction Circuit
1.2.3 The presubiculum is a major contributor of spatial representation and memory
1.3 Information processing in the presubicular microcircuit
1.3.1 Anatomy and intrinsic excitability of presubicular neurons
1.3.2 Interlaminar, intralaminar and modular organization
1.3.3 Input and output relays in the presubicular microcircuit
2 How does a microcircuit work?
2.1 Many integrative levels in neuronal networks
2.2 Neuronal intrinsic excitability
2.2.1 Resting membrane potential
2.2.2 Neuronal passive properties
2.2.3 Action potentials
2.2.4 Firing properties
2.3 Wiring a network: axonal conduction and regulation of information
2.3.1 Axonal conduction velocity
2.3.2 Analog information encoding in the axon
2.4 Synaptic transfer and modulation of information in the presynaptic terminal
2.4.1 Basic mechanism of neurotransmitter release
2.4.2 Synchronous versus asynchronous release of neurotransmitter
2.4.3 Short term presynaptic plasticity
2.4.4 Voltage dependent regulation of synaptic activation
2.4.5 Regulation of presynaptic function by extrinsic factors
II Methods
III Results
ARTICLE 1. Cellular neuroanatomy of rat presubiculum
ARTICLE 2. Properties of presubicular neurons that project to lateral mammillary nucleus or anterodorsal thalamus
ARTICLE 3. A continuum of diversity of Parvalbumin or Somatostatin expressing interneurons in mouse presubiculum
ARTICLE 4. Memory of past activity determines the recruitment of a Martinotti cell-mediated inhibitory feedback loop in mouse presubiculum
IV Discussion
1 Building blocks of the presubiculum
1.1 Did we correctly addressed the whole diversity of principal neurons?
1.2 Interneuron diversity
2 Perspective: from neuronal diversity to function
3 Neurons that project to lateral mammillary (LMN) and anterodorsal thalamus (ADN): implication for the visual update of the head direction signal
4 Memory of past activity at the pyramidal cell-to-Martinotti cell synapse: properties and mechanisms
4.1 Better define the dynamics of the plasticity, its specificity and variability
4.2 Mechanisms of activity dependent synaptic transfer at the pyramidal cell to Martinotti cell synapse?
4.2.1 Activity dependent action potential broadening
4.2.2 Modulation at the synapse
4.2.3 The transfer rate increase may results from a synergistic mechanism
V General conclusion
VI Collaboration
ARTICLE. Cellular anatomy, physiology and epileptiform activity in the CA3 region of Dcx knockout mice: a neuronal lamination defect and its consequences
List of figures
Bibliography
