Influence of the human skull on displacement profiles

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Table of contents

CHAPITRE 1 RESUME EN FRANÇAIS
1.1 Introduction
1.2 HIFU transcrâniens
1.3 Objectif de la thèse
1.4 Localisation des ultrasons par MR ARFI
1.5 Neuromodulation sur les rats
1.6 Neuromodulation sur singe éveillé
CHAPITRE 2 INTRODUCTION
2.1 Introduction
2.2 Transcranial HIFU
CHAPITRE 3 KEYHOLE ACCELERATION FOR MAGNETIC RESONANCE ACOUSTIC RADIATION FORCE IMAGING (MR ARFI)
3.1 Introduction
3.2 MR ARFI
3.3 Influence of the human skull on displacement profiles
3.4 Keyhole
3.5 Keyhole and MR ARFI: simulations
3.6 Ex-vivo experiments
3.7 Results
3.7.1 Simulated data
3.7.2 Experimental MR ARFI data
3.7.3 Experimental evaluation of the influence of the skull on the intensity profile
3.8 Discussion
3.9 Conclusion
CHAPITRE 4 NEUROMODULATION ON RATS
4.1 Introduction
4.2 Experimental setup
4.3 Ultrasound sequence and calibration
4.4 Preliminary experiments
4.5 Animal preparation and ultrasound neuromodulation protocol
4.6 Numerical simulation of the experimental setup
4.7 Results
4.7.1 Ultrasound pressure calibration through the half skulls
4.7.2 Ultrasound neuromodulation experiments
4.7.3 Pressure threshold
4.7.4 Acoustic numerical simulation of the experiment
4.8 Discussion
4.9 Conclusion
CHAPITRE 5 NEUROMODULATION ON THE AWAKE MONKEY
5.1 Introduction
5.1.1 Frontal Eye Field
5.1.2 Antisaccade
5.1.3 Objectives
5.2 Focused ultrasound
5.3 Task
5.4 Experimental protocols
5.5 Surgical procedure
5.6 Data analysis and presentation
5.7 Results
5.7.1 Focused ultrasound-modulated antisaccade latencies
5.7.2 Focused ultrasound Effect on Antisaccade Error Rate and Amplitude
5.8 Discussion
5.9 Conclusion
GENERAL CONCLUSION
ACKNOWLEDGEMENTS
BIBLIOGRAPHIE