A common scaling rule for cell number in all mammalian brains

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Table of contents

1 Introduction 
1.1 The primate cerebral cortex: organization and evolution
1.1.1 The cerebral cortex: general organization and composition
1.1.2 Radial organization of the cerebral cortex
1.1.3 Tangential organization of the cerebral cortex
1.1.4 Evolution and specificities of the primate cerebral cortex
1.2 Corticogenesis: lessons from rodent models
1.2.1 Overview of mouse cortical development
1.2.2 Specification of the cerebral cortex territories
1.2.3 Inside-out generation of the cortical layers
1.2.4 Origin of excitatory neurons
1.3 Toward a better understanding of primate corticogenesis
1.3.1 The primate cortical lamination is also inside-out
1.3.2 A more complex early cortical development in primates
1.3.3 Multiple origins of primate interneurons?
1.3.4 An extra proliferative zone: the OSVZ
1.3.5 Towards the identification of the primate cortical precursors heterogeneity and diversity
1.3.6 Mechanisms of cortical gyrification
1.3.7 Hypotheses for primate cortical expansion
2 Results 
2.1 Paper in press at Neuron: Precursor diversity and complexity of lineage relationships in the outer subventricular zone of the primate
2.1.1 Abstract
2.1.2 Introduction
2.1.3 Results
2.1.4 Discussion
2.1.5 Material and methods
2.1.6 Acknowledgements
2.1.7 References
2.1.8 Figures
2.1.9 Supplemental information
2.2 Cell lineage analysis in the primate germinal zones based on a Hidden Markov Tree model
2.2.1 Introduction
2.2.2 Methods
2.2.3 Results
2.2.4 Discussion
3 General discussion 
3.1 Mechanisms for neuronal output amplification in primate cortical development
3.1.1 Candidate proteins for primate cortical expansion : proteins involved in rodent BP pool amplification
3.1.2 A time-dependent cell cycle duration / mode of division regulation allowing an upsurge of proliferation
3.2 Diversity of precursor types and complex lineage relationships in the primate developing cortex
3.2.1 5 types of precursors in the primate OSVZ
3.2.2 An emerging neuronal lineage complexity during evolution?
3.3 Hypothesis for the origin of precursor type diversification and lineage relationships complexification during evolution
3.3.1 The metaphor of Waddington epigenetic landscape
3.3.2 Di↵erent landscapes in mouse and primate cortical developments?
3.4 General conclusion