AhR-Dependent Genes and Negative Feed-Back Regulation of the AhR Signalling

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Table of contents

Chapter 1. Introduction 1 The gastrointestinal tract 
1.1.1. Stomach
1.1.2. Intestines 3 The immune system in the GI tract
The Human Gut Microbiota
1.3.1. Composition of the gut microbiota
1.3.2. Development and age-related variation of gut microbiota
1.3.3. The study of gut microbiota 18 The Role of Gut Microbiota in the Host-Bacteria Cross-Talk
1.4.1. The Barrier Homeostasis in Intestine
1.4.2. Mechanisms for Sensing Microbial Signals by IECs
1.4.3. Intestinal Microbiota and the Immune System beyond the Gut
1.4.4. Microbial-derived Metabolites in Host-Bacterial Cross-Talk
1.4.5. Dysbiosis in Human Pathology
Aryl Hydrocarbon Receptor: Description, Characterization and Physiological Role
1.5.1. Expression and Localization
1.5.2. Structure and Functional Domains
1.5.3. AHR pathway
1.5.4. Physiological role of AhR
1.5.5. Cross-talk with other signalling pathways
Chapter 2. Rationale and Objectives 
Chapter 3. Results 
Paper I: Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells
Paper II: Identification of Bifidobacteria as novel activators of AhR pathway in human intestinal epithelial cells 
Chapter 4. Discussion 
Chapter 5. Supplementary 
Choline-TMA catabolism by gut microbiota
5.1.1. Comments on Objectives and Methods
5.1.2. Experimental set-up
5.1.3. Comments on the Results and Discussion
Bibliography