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Table of contents
1. Synthèse de donneurs de NO
Synthèse de SNOC (S-nitrosoglutathione-oligosaccharides de chitosan)
Synthèse de la SNA (S-nitrosoglutathione-alginate)
2. Microparticules préparées par spray drying : GSH /Eudragit® FS30D et GSNO/Eudragit® FS30D
1. Nitric oxide
Nitric oxide in central nervous system and its action as a neurotransmitter:
Nitric oxide in hypertension
Nitric oxide in immune system
NO and regulation of intestinal function
Nitric oxide and progression of renal disease
Nitric oxide in cancer
Anti-inflammatory effects of NO
2. NO donors
NO donor drugs
Organic nitrates and nitrites
S-nitrosothiols
3. Polymeric carriers for NO
3.1. Micro/nanoparticles
3.2. Thiomers
3.3. Non-biodegradable polymers : Eudragit®
4. Intestine and management of Crohn’s disease
4.1. Small intestine
4.2. Large intestine
4.3. Intestinal barriers to the absorption
5. Crohn’s disease
5.1. Treatment of Crohn’s disease
Objectifs
Results and Discussions
Chapter 1: Synthesis and characterization of S-nitrosoglutathione-oligosaccharide-chitosan as a nitric oxide donor
Chapter 2: Synthesis of S-nitrosoglutathione-alginate for prolonged delivery of nitric oxide in intestines
Chapter 3: Spray dried microparticles of glutathione and S-nitrosoglutathione based on Eudragit® FS 30D polymer
Discussion générale (anglais) Conclusion et perspectives (français)
Discussion générale (anglais)
1. Polymer formulations
1.1. Nitrosation of conjugates
1.2. Stability studies
1.3. Permeability studies in the Ussing chamber
1.4. Cytotoxicity studies in the Caco2 cell line
2. GSH and GSNO spray dried microparticles based on Eudragit® FS 30D polymer
2.1. Physical characterization
2.2. In vitro drug release behaviour
2.3. Advantages of spray drying
3. Perspectives
Conclusion et perspectives
References
