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Table of contents
Chapter I
1 Surfactant systems
1.1.1 Molecular structure
1.1.2 Hydrophilic-lipophilic balance (HLB) system
1.1.3 Organized molecular assemblies
Nano-emulsions
2 Porous Silica Materials
Mesoporous Materials
2.2.1 Cooperative templating mechanism – CTM
2.2.2 Liquid crystal/emulsion templating
2.3.1 Meso-macroporous materials
2.3.2 Bimodal mesoporous materials
3 Application fields
3.1.1 Effects of porous silica materials properties on drug loading and release
3.1.2 Hybrid materials as carriers of active ingredients
3.1.3 Active ingredient: Ketoprofen
3.2.1 Lipase
3.2.2 Catalytic mechanism of the lipase
3.2.3 Enzyme immobilization on porous silica materials
3.2.4 Effect of the properties of porous material
4 Aim of this thesis
5 References
Chapter II
1 Materials
Oils
Silica source
Enzymes
2 Methods
2.1.1 Polarized light microscopy
2.2.1 Phase Inversion Composition – PIC
2.2.2 Phase Inversion Temperature – PIT
2.2.3 Conductivity measurements
2.2.4 Dynamic light scattering
2.2.5 Nanoparticle Tracking Analysis – NTA
Drug release
Transesterification
2.5.1 Enzyme physisorption on silica substrates
2.5.2 Adsorption isotherm
2.5.3 Transesterification of Colza oil
2.5.4 Purification of the transesterification reactions products
2.5.5 Gas chromatography
2.5.6 Yield calculation of the transesterification reaction
3 Characterization methods
3.1.1 Lamellar phase
3.1.2 Hexagonal phase
3.1.3 Mesoporous material
3.2.1 Type II isotherm
3.2.2 Type IV isotherm
Electronic microscopy
3.4.1 Scanning Electronic Microscopy – SEM
3.4.2 Transmission Electronic Microscopy – TEM
4 References
Chapter III Detailed investigation of nano-emulsions obtained from the Remcopal 4/decane/water system
Nano-emulsions as imprints for the design of hierarchical porous silica through a dual templating mechanism
Hybrid hierarchical porous silica templated in nano-emulsions for drug release
1 Biocompatible nano-emulsions
Characterization
Release Experiment of the Ketoprofen from the Biocompatible Nano-emulsions
Silica materials templating
2 References
Chapter IV
1 Introduction
2 Thermal stability of the hierarchically porous the silica material
Thermal stability of the dual-mesoporous silica materials
3 Hydrothermal stability of the hierarchically porous silica material
Hydrothermal stability of dual-mesoporous silica material
Comparison and discussion
4 Mucor miehei Lipase immobilization
4.1.1 Adsorption isotherm
4.1.2 Characterization of the meso-macroporous biocatalyst
4.2.1 Adsorption isotherm
4.2.2 Characterization of the dual-mesoporous biocatalyst
5 Transesterification reaction of colza oil
6 Discussion
7 Conclusion
8 References
9 Acylases immobilization
Adsorption isotherm
Conclusion
10 References
