Composition, pharmacology and indications of IVIg

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Table of contents

Acknowledgements
Abbreviations
Résumé
1. Introduction
1.1. Immune system
1.2. Immune homeostasis and activation
1.3. T cell polarization and Th cells subsets.
1.3.1. Th1 cells
1.3.2. Th2 cells
1.3.3. Th17 cells
1.3.4. Regulatory T cells
1.4. mTOR integrates multiple signals during T cell activation
2. T cells in autoimmunity : shifting paradigms from Th1/Th2 to Th17/Tregs
2.1. Th1/Th2 hypothesis and the emergence of Th17 cells
2.2. Dysregulated equilibrium between pathogenic and regulatory T cells leads to immune disease
3. Intravenous Immunoglobulin
3.1. Composition, pharmacology and indications of IVIg
3.2. Immunoregulatory mechanisms of IVIg in autoimmune and inflammatory diseases.
3.3. Modulation of the Tregs by IVIg
4 Multiple sclerosis/ EAE is an organ specific T cell mediated auto-immune disease
5 Hypothesis and aims
6 Results
7 Discussion and Perspectives
8 References
Annexes