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Table of contents
ABBREVIATIONS
INTRODUCTION
I-Cell cycle regulation in plants
A-Plant CDKs and Cyclins, motors of cell cycle progression with an intriguing diversity
B-Control of the G1/S transition: the E2F/RBR pathway
C-Regulation of G2 and mitosis
D-Cell Cycle regulation in response to stress
II-DNA replication
A-Regulation of replication initiation
B-Organisation and function of the replisome (elongation and termination of replication)
III-Polymerase epsilon (DNA polymerases)
A-Structure and properties of DNA polymerases
B-Specificities of Pol ε subunits
C- Roles of Pol ε subunits at different steps of DNA replication
IV- Mechanisms involved in the maintenance of genome integrity
A-Genotoxic Stress
B-DDR in Mammals and Plants
C- Specific mechanisms triggered by replicative stress
V-Replicative polymerases in plants
A-Polymerase α
B- Polymerase δ
C-Polymerase ε
Results
First article: Role of the Polymerase ϵ sub-unit DPB2 in DNA replication, cell cycle regulation and DNA damage response in Arabidopsis. Published in Nucleic Acids Research (2016, Epub ahead of print).
Second article: Function of the plant DNA Polymerase epsilon in replicative stress sensing, a genetic analysis
Discussion
Role of Pol sub-units during the replicative stress response in somatic cells
Role of Pol in an adaptation checkpoint involved in DNA damage tolerance
Roles of Pol sub-units during the pre-meiotic DNA replication and meiosis progression
PERSPECTIVES
Function of Pol ε subunits
Pol ε complex and interactions
A link between DNA Damage Response and auxin signaling?
REFERENCES
