Detecting Pathogens Interactions

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Table of contents

1 Introduction
1.1 Modéliser les épidémies
1.2 Interactions entre pathogènes
1.3 Interactions et Santé Publique
1.4 Les objectifs de la thèse
2 Une nouvelle définition de la susceptibilité
2.1 Interactions multiples
2.2 Conséquences pour la Santé Publique
3 Détection des interactions entre pathogènes
3.1 Le modèle
3.2 Causalité de Granger
3.3 Transfert d’Entropie
3.4 Application
3.5 Discussion
4 Interactions et Santé Publique : cas de la vaccination contre la Dengue
4.1 Le modèle
4.2 Discussion
5 Conclusion
5.1 Perspectives
Introduction
1 Modelling Infectious Diseases
1.1 Basic reproductive rate, Epidemic threshold and Herd immunity
1.2 Other developments of Epidemiology
2 Pathogen-pathogen Interactions
3 Detecting Pathogens Interactions
3.1 Correlation and Causality
4 Implications for Public Health
5 The objectives of this PhD
Chapter 1 Interactions between pathogens and the need for a new definition of population susceptibility
1.1 Introduction
1.2 Parasite-parasite Interaction Mechanisms
1.2.1 Cross-immunity
1.2.2 Immune cross-regulation
1.2.3 Immunosupression
1.2.4 Reducing availability of susceptible individuals
1.2.5 Increased availability of susceptible individuals or perturbation of behavioral resistance
1.3 Simultaneous Parasite-parasite Interactions: a Review of (non-existing) Studies .
1.3.1 Immunity suppression and cross-immunity
1.3.2 Immunity suppression and cross-regulation
1.3.3 Immunity suppression and permanent reduction of susceptible abundance
1.3.4 Cross-immunity and temporary decrease of susceptible abundance
1.3.5 Cross-immunity and permanent reduction of susceptible abundance
1.3.6 Cross-regulation and temporary reduction of susceptible abundance
1.4 Simultaneous Pathogen Interactions and Public Health Strategies
1.5 How could we consider the myriad of interactions? Perspectives for a Global Health 19
Chapter 2 Detecting interactions between pathogens
2.1 Introduction
2.2 Methodology
2.2.1 The Model
2.2.2 Granger Causality
2.2.3 Transfer Entropy
2.3 Results
2.3.1 Model Behaviour
2.3.2 Granger Causality
2.3.3 Transfer Entropy
2.4 Discussion
Chapter 3 Vaccine Heterogeneity and Serotype Interactions
3.1 Introduction
3.2 Methods
3.3 Results
3.4 Discussion
Conclusion
1 Results of the PhD
1.1 Review of the Literature
1.2 Identifying Interactions
1.3 Interactions and Public Health Policies
2 Contextualisation of the Findings
3 Perspectives for this PhD
Lessons from this PhD
Bibliography