Diffuse Optical Tomography

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Table of contents

Introduction
1 Light propagation in thick scattering media
1.1 Of the interest of optical imaging
1.2 Light-matter interaction
1.2.1 Absorption
1.2.2 Scattering
1.2.3 Orders of magnitude in biological tissues
1.3 Light propagation in scattering media
1.3.1 Propagation regimes
1.3.2 Speckle
1.4 Optical imaging in scattering media
1.4.1 Imaging with ballistic light
1.4.2 Imaging with multiply scattered light
1.5 Conclusion
2 Acousto-optic imaging
2.1 Principle of acousto-optic imaging
2.1.1 The acousto-optic effect
2.1.2 Applications of the technique
2.2 Light modulation in scattering media
2.2.1 Modulation of the scatterers positions
2.2.2 Modulation of the refractive index
2.2.3 Coherent acousto-optic modulation
2.3 Image formation and resolution
2.4 Detection of tagged photons
2.4.1 Incoherent methods
2.4.2 Coherent methods
2.5 Conclusion on acousto-optic imaging
3 Photorefractive detection of tagged photons
3.1 The photorefractive effect
3.1.1 Principle
3.1.2 The band-transport model
3.1.3 Characteristics of the photorefractive effect
3.2 Detection of the acousto-optic signal
3.2.1 Two-wave mixing
3.2.2 Acousto-optic signal detection
3.2.3 Experimental configuration
3.3 Choice of the crystal
3.3.1 Measurement of the crystals characteristics
3.3.2 SPS vs. ZnTe
3.4 Conclusion
4 Acousto-optic imaging in reflection mode
4.1 Fusion between conventional ultrasound and Acousto-Optic Imaging
4.2 Monte Carlo Simulations
4.2.1 The algorithm
4.2.2 Influence of source-detector distance
4.3 Imaging in reflection mode
4.3.1 The imaging setup
4.3.2 Influence of source-detector distance
4.3.3 Towards a handheld probe
4.3.4 A multiple detector approach
4.4 Towards In Vivo imaging
4.5 Conclusion
5 Inverse Problems for Quantitative Acousto Optic Imaging
5.1 Inverse problems for medical imaging
5.1.1 Definition of an inverse problem
5.1.2 Reconstruction algorithms
5.1.3 Application to imaging
5.2 Inverse problems for acousto-optic imaging
5.2.1 The inverse problem and model corrections
5.2.2 Reconstruction of the absorption coefficient
5.2.3 Limitations of the current algorithm
5.2.4 Next steps for quantitative acousto-optic imaging
5.3 Conclusion
Conclusions and perspectives
References