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Table of contents
CHAPTER ONE : INTRODUCTION
1.1 EPIGENETICS OVERVIEW
1.2 INTRODUCTION ON CHROMATIN
1.2.1 Euchromatin & Heterochromatin
1.3 GLOBAL CHROMATIN MODIFICATIONS
1.3.1 Histone Post-translation Modifications
1.3.2 DNA Methylation
1.4 CENTROMERIC & PERICENTROMERIC HETEROCHROMATIN
1.5 HISTONE H3 AND ITS SERINE 10 PHOSPHORYLATION
1.5.1 H3S10P in somatic cells
1.5.2 H3S10P in mammalian gametes
1.6 THE MOUSE AS A MODEL
1.6.1 Preimplantation development
1.6.2 Mouse preimplantation development
1.6.3 Heterochromatin in embryos
1.7 H3S10P IN MAMMALIAN EMBRYOS
1.8 SOMATIC CELL NUCLEAR TRANSFER (SCNT)
1.8.1 SCNT and its issues
1.8.2 Epigenetic reprogramming after SCNT
1.8.3 TSA and the improvement of reprogramming after SCNT
1.8.4 Pericentromeric Heterochromatin remodelling after SCNT
1.9 PROJECT AIMS
CHAPTER TWO: H3S10 PHOSPHORYLATION MARKS CONSTITUTIVE HETEROCHROMATIN DURING INTERPHASE IN EARLY MOUSE EMBRYOS, UNTIL THE 4-CELL STAGE
2.1 INTRODUCTION
2.1 ORIGINAL PAPER #1
2.2 SUPPLEMENTARY FIGURES
CHAPTER THREE: NUCLEAR DYNAMICS OF HISTONE H3 TRIMETHYLATED ON LYS9 AND/OR PHOSPHORYLATED ON SER10 IN MOUSE CLONED EMBRYOS AS NEW MARKERS OF REPROGRAMMING?
3.1 INTRODUCTION
3.2 ORIGINAL PAPER #2
3.3 SUPPLEMENTARY FIGURE: IMMUNODETECTION OF H3S10P IN IVF EMBRYOS
CHAPTER FOUR: GENERAL DISCUSSION & PERSPECTIVES
BIBLIOGRAPHY
