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Table of contents
Chapter I: General introduction
1.1 HSC definition and HSC differentiation models
1.2 Lineage tracing in the study of HSC differentiation
1.3 Lineage tracing of HSC at the single cell level by cellular barcoding
1.4 Lineage tracing reveals heterogeneity in HSC output-HSCs are “biased”
1.5 The effect of cytokines on HSC differentiation
1.6 Erythropoietin and HSCs
1.7 Aims of my thesis
Chapter 2: Early HSC engraftment kinetics at the single cell level
2.1 Introduction
2.2 Results
2.3 Discussion
2.4 Materials and methods
2.5 Supplementary information
Chapter 3: The effect of erythropoietin on HSC differentiation
3.1 Introduction
3.2 Results
3.3 Discussion
3.4 Materials and methods
3.5 Supplementary information
Chapter 4: What next? Outlook on cellular barcoding
4.1 The promises of available HSC barcoding libraries
4.2 HSC barcoding entering the “omics” era
4.3 HSC barcoding and other dimensions
4.4 Beyond the single-cell level, intra-clonal heterogeneity



