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Table of contents
ACKNOWLEDGMENTS
ABBREVIATIONS
PREFACE
INTRODUCTION
1. The immune tolerance
1.1 Central tolerance
1.2 Peripheral tolerance
2. Foxp3+CD4+Regulatory T cells
2.1 Discovery
2.2 Phenotypic markers
2.3 Features of Treg stability and activation
2.4 Treg development
2.4.1 Development of tTreg
2.4.2 Development of pTreg
2.5 Treg stability and plasticity
2.5.1 Treg stability
2.5.2 Class control
2.6 Role of tTreg and pTreg
2.6.1 Autoimmunity
2.6.2 Allergies and asthma
2.6.3 Infections
2.6.4 Pregnancy
2.6.5 Tumors
2.6.6 tTreg and pTreg
2.7 Impact of inflammatory cytokines on Treg
2.8 Mechanisms of suppression
2.8.1 Suppression by inhibitory cytokines
2.8.2 Suppression by cytolysis
2.8.3 Suppression by metabolic disruption
2.8.4 Suppression by targeting dendritic cells
3. Role of Tumor Necrosis Factor Receptor Super Family (TNFRSF) in T cells
3.1 The discovery of the TNFSF
3.2 Structure
3.3 Signaling
3.4 General features on the roles of TNFRSF members
3.4.1 TNFRSF members and Tconv
3.4.2 TNFRSF members and Treg
3.4.3 TNFRSF members and disease
3.5 TNFR
3.5.1 Expression and main features
3.5.2 Role in AD
3.5.3 Role in cancer
3.5.4 Role in Tconv
3.5.5 Role in Treg
3.6 GITR
3.6.1 Expresion and main features
3.6.2 Role in AD
3.6.3 Role in cancer
3.6.4 Role in Tconv
3.6.5 Role in Treg
3.7 4-1BB
3.7.1 Expression and main features
3.7.2 Role in AD
3.7.3 Role in cancer
3.7.4 Role in Tconv
3.7.5 Role in Treg
3.8 OX40
3.8.1 Expression and main features
3.8.2 Role in AD
3.8.3 Role in cancer
3.8.4 Role in Tconv
3.8.5 Role in Treg
3.9 DR3
3.9.1 Expression and main features
3.9.2 Role in AD
3.9.3 Role in Tconv
3.9.4 Role in Treg
3.10 Other TNFRSF members
3.10.1 CD30
3.10.2 HVEM
3.10.3 CD40
3.10.4 CD27
3.10.5 DR5
AIM OF WORK
PAPER
ADDITIONAL RESULTS
DISCUSSION
1. The importance of Treg and TNFRs
2. Role of TNFRs members in Treg biology
3. Role of TNFRs in iTreg
BIBLIOGRAPHY
