(Downloads - 0)
For more info about our services contact : help@bestpfe.com
Table of contents
CHAPTER ONE: CORONAVIRUSES
I. History and classification
I.1. History
I.2. Classification
II. Biology of Coronaviruses
II.1. Morphology of the virion
II.2. Genome organisation
II.3. Structural proteins
II.3.1. The spike S glycoprotein
II.3.2. The envelope E protein
II.3.3. The M protein
II.3.4. The N protein
II.3.5. The hemagglutinin-esterase (HE) protein
II.4. Non-structural proteins
II.5. Accessory proteins
III. Virus life cycle
III.1. Virus attachment and entry
III.2. Viral RNA synthesis
III.3. Assembly and release of the virions
IV. Human and veterinary diseases
IV.1. Human diseases
IV.1.1. Human Coronaviruses associated with mild respiratory diseases
IV.1.2. Severe acute respiratory syndrome virus-SARS-CoV
IV.1.3. Middle East respiratory syndrome virus-MERS-CoV
IV.2. Domesticated animal diseases
IV.2.1. Infectious bronchitis virus
IV.2.2. Porcine Coronaviruses
IV.2.3. Feline enteric Coronavirus and feline infectious peritonitis virus
IV.2.4. Canine Coronaviruses
IV.3. Molecular determinants of pathogenesis
IV.3.1. Tropism switch and pathogenesis
IV.3.2. Interaction with the host innate immune response
IV.3.3. Roles of the accessory proteins in pathogenesis
CHAPTER TWO: CORONAVIRUS INTERSPECIES TRANSMISSIONS AND ADAPTATION TO A NEW HOST
I. Understanding the interspecies transmission
I.1. Exposure
I.2. Infection
I.3. Host adaptation
II. From animal Coronaviruses to zoonotic diseases
II.1. HCoV-OC43 strain: a strictly human respiratory virus with bovine origins
II.2. From bat SARS-CoV to SARS-CoV
II.3. Emergence of the MERS-CoV: role of the dromedary camel
III. Interspecies transmissions among animal Coronavirus
III.1. Avian Coronaviruses
III.2. Feline, canine and porcine Coronaviruses
III.3. Available models for the study of Coronavirus inter-species transmissions
OBJECTIVES OF THESIS PROJECT
INFECTIONS OF CATS WITH ATYPICAL FELINE CORONAVIRUSES HARBOURING A TRUNCATED FORM OF THE CANINE TYPE I NON-STRUCTURAL ORF3 GENE .
CHARACTERIZATION OF DIFFERENT FORMS OF THE ACCESSORY GP3 CANINE CORONAVIRUS TYPE I PROTEIN IDENTIFIED IN CATS
DISCUSSION
I. Infections of cats by strains harbouring the CCoV-I ORF3 gene
II. Characterisation of the deleted forms of the accessory glycoprotein 3 (gp3)
III. Perspectives
GENERAL CONCLUSION
BIBLIOGRAPHY
