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Table of contents
Introduction
Biological context
cheese manufactured at pilote-scale
Main features of bacterial metabolism during cheese production
Experimental design of the TANGO project
Community modeling
Interactions
How to model them?
Modeling the bacterial metabolism
Metabolic network
Metabolic network reconstruction
Mathematical models of metabolism
Dynamic modeling using ODE
Materials & Methods 20
GEM reconstruction
FBA model construction and assessment
Omics data integration
Software availability
Results
Genome scale metabolic network Model (GEMs) reconstruction Interest of three different annotations tools
Draft models
Gap-lling and curation
Focus on organoleptic compounds
At genome scale
At community scale
Integration of metatranscriptomics data
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UNIVERSITY OF BORDEAUX
Community model



