FOXP2 deficiency causes a complex speech and language disorder

For more info about our services contact : help@bestpfe.com

Table of contents

Introduction
FOXP2 deficiency causes a complex speech and language disorder
Foxp2 as an entry point to study molecular and neural networks contributing to cognitive aspects of speech and language
The study of animal models provides insights into conserved FoxP2 functions
The role of FoxP2 in development
Activity dependent function of FoxP2 in mature brain: evidence for a role in social behaviour and vocalizations
FoxP2 cellular functions
Mouse models in Foxp2 research: motor learning and ultrasound vocalizations
Foxp2 in the mouse cortex
Context
Aims 
Materials and Methods
Mice
Histological analysis
Analysis of projections: brain stereotaxic injections
Expression analysis
Behavioral tests
Ultrasonic vocalizations (USV)
Cell type–specific mRNA purification by translating ribosome affinity purification (BacTRAP)
Results
1. Generation and characterization of Foxp2 cortex-specific homozygous knockout mice
1.1. Cortical Foxp2 ablation does not affect gross cortical morphology
1.2. Foxp2 cKO animals do not show gross projection abnormalities
1.3. Postnatal development of Foxp2 cKO mice and WT littermates is indistinguishable
1.4. The role of cortical Foxp2 in DA signaling related behavior
1.5. Social interaction defects in Foxp2 cortical knockout mice
1.6. The role of cortical Foxp2 in modulating ultrasonic vocalizations (USVs)
2. Molecular profiling of lower cortical neurons in Foxp2+/- mice
3. Autism related gene-Mint2- is downregulated in the cortex of Foxp2 cKO mice