How many mechanisms do Tregs need ? Treg plasticity

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Table of contents

Acknowledgement
Index of figures
Index of tables
Abstract
Abbreviations
A. Introduction
1. Immune system and tumors: a complex discourse
1.1. Origin of the concept of tumor microenvironment
1.2. Origin and concept of immune surveillance
1.2.1. Immunoediting: 3 `E’ concept
1.3. Tumor microenvironment: a complex interactome
1.3.1. Characteristics of contexture
1.3.2. Cancer associated TLS
1.3.2.1. General characteristics of TLS
1.3.2.2. Formation of TLS
1.3.3. TLS in anti-tumor immune response
1.4. Infiltration of immune cells in solid tumor: a strong prognostic marker ..
1.4.1. Prognostic importance of the TLS in cancer
2. Tregs: Key Regulators of anti-tumor immune response
2.1. Discovery and features of regulatory T cells
2.2. Regulatory T cell subsets
2.3. Regulatory mechanisms exerted by Tregs
2.3.1. Inhibitory cytokines
2.3.2. Suppression by cytolysis
2.3.3. Suppression by metabolic disruption
2.3.4. Cell to cell contact dependent suppression: Involvement of co-stimulatory and co-inhibitory signals
2.4. How many mechanisms do Tregs need? Treg plasticity
2.5. Infiltration, differentiation and activation of Tregs in tumor microenvironment
2.5.1. Infiltration of Tregs in tumor microenvironment
2.5.2. Expansion and activation of Tregs
2.5.3. Antigen specificity of Tregs in cancer
2.6. Tregs in cancer: ambiguity in prognostic importance
3. Tregs and immunotherapy: a blessing in disguise?
4. Lung cancer: a study model
4.1. Etiology and histology of the lung cancer
4.2. TNM classification and survival of patients
4.3. Treatment of lung cancer patients
4.4. Era of combined therapies: promising for NSCLC
B. Hypothesis and objectives
C. Results
References
Tregs in advanced stage chemotherapy treated lung cancer patients
D. Discussion
TLS in lung tumors: centers of the protective immune responses
Infiltration, activation of Tregs in cancer microenvironment
Anti-inflammatory role of Tregs in lung cancer
Tregs in TLS: Proponents or opponents?
Expansion of the specific subsets of Tregs in TLS
Modulation of the Treg phenotype in the neoadjuvant chemotherapy treated lung cancer
Prognostic outcome of Tregs in lung cancer patients
E. Limitations of this study
F. Conclusion and perspectives
G. References
Publication bibliography
H. Annex