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Table of contents
ACKNOWLEDGMENTS
ABBREVIATIONS
RÉSUMÉ
ABSTRACT
RÉSUMÉ DE LA THÈSE
CHAPTER 1. THE SKELETAL MUSCLE NEIGHBORHOOD
1. Generalities about skeletal muscle
1.1. Skeletal muscle structure and function
1.2. Embryonic development of vertebrate limb skeletal muscles
2. Postnatal skeletal muscle stem cells
2.1. The satellite cell
2.2. Non-satellite muscle progenitors
3. Influence of the niche on stem cell behavior
3.1. “External” signals: the action of inflammatory cells
3.2. “Internal” signals: the myogenic/adipogenic balance
CHAPTER 2. MECHANISMS REGULATING SKELETAL MUSCLE MASS
1. Changes in muscle mass throughout life
1.1. Muscle hypertrophy during postnatal growth and physical training
1.2. Age and disease-related loss of muscle mass
2. The major signaling pathways regulating muscle size
2.1. Myostatin, a potent inhibitor of muscle mass
2.2. Myostatin non-canonical pathways
2.3. A myostatin endogenous antagonist: follistatin
3. Pharmaceutical approaches to induce skeletal muscle hypertrophy
3.1. Targeting muscle mass via myostatin inhibition
3.2. Satellite cells and muscle hypertrophy
RATIONALE. Introduction at a glance and objectives of the thesis
CHAPTER 3. DEFINING THE POSITION OF PICS IN THE SKELETAL MUSCLE STEM CELL HIERARCHY.
CHAPTER 4. DEFINING THE ROLE OF PICS IN ADULT SKELETAL MUSCLE.
CHAPTER 5. DISCUSSION
1. PICs: multipotent progenitors or mixed population?
1.1. Adult PICs versus juvenile PICs
1.2. Adult PICs versus other stem cells of the skeletal muscle niche
2. PICs as a therapeutic target
2.1. PICs are a source of positive signals for muscle growth
2.2. PICs constitute an easily recruitable population
REFERENCES
APPENDIX 1
APPENDIX 2
