Investigations of dendrimer toxicity

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Table of contents

CHAPTER I. LITERATURE REVIEW
I. Polyelectrolyte multilayer (PEM) films
I.1. Polyelectrolyte multilayer (PEM) films obtained by electrostatic interactions
I.1.1. Properties of polyelectrolytes
I.1.2. Strong polyelectrolytes versus weak polyelectrolytes
I.1.3. History of polyelectrolyte multilayer films
I.1.4. Principles of the Layer by Layer (LBL) deposition of PEM films
I.1.5. Interactions in multilayer LBL films
I.1.6. Charge balance in polyelectrolyte multilayers
I.1.7. Growth modes of multilayer films
I.1.7.1. Films with linear growth
I.1.7.2. Films with exponential growth
I.1.8. Physico-chemical parameters affecting the growth of PEM films
I.1.8.1. Solution pH
I.1.8.2. Ionic strength of the buffer and polyelectrolyte solutions
I.1.8.3. Buildup temperature
I.1.8.4. Effect of salt anion on the film construction
I.1.9. Mechanical properties of PEM films
I.1.10. Water content in PEM films
I.2. Polyelectrolyte multilayer films obtained by hydrogen bonding
I.3. Electrochemical properties of polyelectrolyte multilayers
I.3.1. Ion Permeability of polyelectrolyte multilayers
I.3.2. Donnan Potential in PEM films
I.4. Applications of PEM films
I.5. Incorporation of Nanoparticles and Biomolecules into PEM Films
I.5.1. Incorporation of bioactive molecules and ions
I.5.2. Incorporation of Nanocolloids
I.5.3. Incorporation of proteins and peptides
I.5.4. Loading with Multivalent ions
I.5.5. Loading of nanoparticles in PEM films
II. Electrokinetic Investigations of Nanodendrimers
II.1. Concept of soft particles
II.2. Electrokinetics of soft particles
II.3. Polyamidoamine (PAMAM) carboxylated nanodendrimers
II.3.1. Synthesis and structure
II.3.2. Advances in nanodendrimers research and applications
II.3.3. Investigations of dendrimer toxicity
CHAPTER II. MATERIALS AND CHARACTERIZATION METHODS
I. Materials and samples preparation
I.1. The polyelectrolyte solutions
I.2. Construction of the films
I.3. Heating and aging of the films
I.4. Electrokinetics of the nanodendrimers
I.5. Loading the films with nanodendrimers
II. Characterization Methods
II.1. Atomic force microscopy (AFM)
II.1.1. AFM technique and principles
II.1.2. AFM cantilevers and probes
II.1.3. Different AFM modes
II.1.4. Force measurements
II.1.5. Determining film elastic modulus using AFM
II.2. Quartz Crystal microbalance-dissipation (QCM-D)
II.3. Confocal Raman Spectroscopy (CRS)
II.4. Dynamic light scattering (DLS) and Phase Analysis light Scattering (PALS)
II.4.1. Size measurements by DLS
II.4.2. Electrophoretic mobility measurements by PALS
CHAPTER III. REMARKABLE ELECTROKINETIC FEATURES OF CHARGE-STRATIFIED SOFT NANOPARTICLES: MOBILITY REVERSAL IN MONOVALENT AQUEOUS ELECTROLYTE
CHAPTER IV. REMARKABLE STRUCTURE AND ELASTICITY RELAXATION DYNAMICS OF POLY(DIALLYLDIMETHYLAMMONIUM CHLORIDE)-POLY(ACRYLIC ACID) MULTILAYER FILMS
CHAPTER V. LOADING OF PAMAM G6.5 DENDRIMERS IN (PDADMAC-PAA) MULTILAYER FILMS
I. Characterization of (PDADMAC-PAA) films
II. Loading of the films with G6.5 PAMAM nanodendrimers
II.1. Effect of G6.5 dendrimers concentration on the morphology of P A MAC PAA films
II.2. Effect of G6.5 concentration on Young modulus of P A MAC PAA films
III. Conclusions
III. References
GENERAL CONCLUSION AND PERSPECTIVES