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Table of contents
CHAPTER I. INTRODUCTION
1. Photodynamic therapy
1.1. History and basic principles
1.2. Basis of PDT therapy
1.3. Mechanisms of PDT action
1.4. Light sources
1.5. Photosensitizers
2. Meta-tetra(hydroxyphenyl)chlorin
2.1. General properties and usage
2.2. Uptake and localization
2.3. Biodistribution and pharmacokinetic properties
2.4. Nanoscale delivery systems
3. Drug-in-cyclodextrin-in-liposome (DCL) nanoplatform
3.1. Liposomes
3.2. Cyclodextrin-based inclusion complexes
3.3. DCL
OBJECTIVES
CHAPTER II. CD INCLUSION COMPLEXES
4. Characterization of inclusion complex formation
5. Development of spectral techniques for monitoring the distribution of inclusion complexes
6. Nanoshuttle mechanism of mTHPC delivery
CHAPTER III. MTHPC-IN-CYCLODEXTRINS-IN-LIPOSOME
7. Development and optimization of mTHPC-DCL
8. Double loaded mTHPC-DCL
GENERAL DISCUSSION
