Metabolic support and protection of axons

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Table of contents

Chapter I: Introduction
I. Multiple sclerosis: Etiology and treatments
1. Foreword
2. Myelin
3. Etiology
4. Clinical description & existing treatments
II. Pathophysiology and Immunopathology of MS
1. Inflammation, demyelination and neurodegeneration
2. Role of T cells in MS and animal models
3. Role of B cells in MS and animal models
4. Role of Macrophages and Microglia in MS and animal models
5. MS Lesions
III. Remyelination
1. Forewords
2. Histological description and clinical relevance
3. Mechanisms of remyelination
4. Remyelination heterogeneity: causes of remyelination failure
IV. Aims of the project
Chapter 2: Evaluation of the role of lymphocytes in remyelination and defining the molecular basis for an efficient myelin repair in patients.
I. Introduction
II. Article 1 and contribution
III. Supplementary unpublished results
IV. Patent
Chapter 3: Linking MS susceptibility variants to remyelination capacity
Chapter 4: Discussion and conclusion
I. Role of lymphocytes in remyelination
1. Experimental evidence
2. Cellular mechanisms involved
3. Modeling LT role in remyelination
II. Enhancing endogenous remyelination: acting directly on OPCs
1. Rational
2. Limitations
III. Deciphering patient’s remyelination heterogeneity to determine the prerequisite for efficient myelin repair in MS
1. Involvement of LT in heterogeneity.
2. Capitalizing on patients with high repair capacities to develop innovative therapeutic targets
3. Genetic variants as the root cause
IV. Conclusion
Bibliography