Migration of muscle progenitors to support limb myogenesis

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Table of contents

ACKNOWLEDGMENTS
LIST OF ABBREVIATIONS
ABSTRACT
INTRODUCTION
CHAPTER 1. SKELETAL MUSCLE DEVELOPMENT, GROWTH, AND REGENERATION
1.1 EMBRYONIC MYOGENESIS: FROM SOMITES TO THE FIRST MUSCLE MASSES
1.1.1 SOMITOGENESIS: FORMATION OF MULTIPOTENT MESODERMAL STRUCTURES
1.1.2 MYOTOME: THE FIRST SKELETAL MUSCLE
1.1.3 MIGRATION OF MUSCLE PROGENITORS TO SUPPORT LIMB MYOGENESIS
1.2 GENETIC HIERARCHIES IN HEAD AND BODY MUSCULATURE ESTABLISHMENT
1.3 PAX PROTEINS AND BHLH MRFS PLAY A CENTRAL ROLE IN THE MYOGENIC PROGRAM
1.3.1 PAX3 AND PAX7 AS UPSTREAM MYOGENIC REGULATORS
1.3.2 MRFS PLAY A CENTRAL ROLE IN MYOGENIC DETERMINATION AND DIFFERENTIATION
1.4 FROM EMBRYONIC MYOGENIC DEVELOPMENT TO POSTNATAL MUSCLE
1.4.1 EMBRYONIC AND FETAL WAVES OF MYOGENESIS
1.4.2 POSTNATAL MUSCLE GROWTH
1.4.3 ADULT MUSCLE: STRUCTURE & FUNCTION
1.5 SATELLITE CELLS: THE SKELETAL MUSCLE STEM CELLS
1.5.1 ESTABLISHMENT DURING DEVELOPMENT
1.5.2 SATELLITE CELLS IN THE CONTROL OF POSTNATAL GROWTH AND HOMEOSTASIS
1.5.3 ACQUISITION OF QUIESCENCE FOR FUNCTION PRESERVATION
1.5.4 SATELLITE CELL NICHE
1.5.5 SATELLITE CELLS IN THE CONTROL OF REGENERATION
1.5.6 SATELLITE CELL HETEROGENEITY
1.5.7 AGING EFFECT IN MUSCLE AND SATELLITE CELLS
CHAPTER 2. CELL CYCLE AND GROWTH ARREST IN SKELETAL MUSCLE AND BEYOND
2.1 CELL CYCLE OVERVIEW
2.2 CDK-CYCLIN COMPLEXES: CELL CYCLE PROGRESSION
2.3 THE POCKET PROTEIN- E2F NETWORK: DOWNSTREAM EFFECTORS OF CDK/CYCLINS
2.4 CDKIS: MAJOR NEGATIVE REGULATORS OF CDK-CYCLIN ACTIVITY
2.5 P57 – “KI P”LAYER IN CELL PHYSIOLOGY AND PATHOLOGY
CHAPTER 3. NOTCH SIGNALING PATHWAY: PLEIOTROPIC ROLE OF A MASTER CELL FATE REGULATOR IN MYOGENESIS
RESULTS
AIMS AND HYPOTHESES
ANTAGONISTIC REGULATION OF p57KIP2 BY HES/HEY DOWNSTREAM OF NOTCH SIGNALING AND MUSCLE
REGULATORY FACTORS REGULATES SKELETAL MUSCLE GROWTH ARREST
A p57 CONDITIONAL MUTANT ALLELE THAT ALLOWS TRACKING OF P57-EXPRESSING CELLS
DISTINCT REGULATION AND FUNCTION OF p21 AND p57 DURING MUSCLE STEM CELL ACTIVATION AND
DIFFERENTIATION
DISCUSSION
CDKIS, MRFS AND NOTCH SIGNALING INTERPLAY IN CELL CYCLE EXIT DURING DEVELOPMENT
CONDITIONAL p57 ABLATION FOR POSTNATAL STUDIES
CDKIS IN THE CONTROL OF SATELLITE CELLS
ANNEX
REFERENCES