Mycotoxins in Feed : impact on pig intestinal health

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Table of contents

INTRODUCTION
I.Context general of study
II.Problem of DON contamination
III.Literature review
A. Mycotoxins in Feed: impact on pig intestinal health (Review n°1)
Introduction
1. Toxicity of the main mycotoxins in pig feed
2. Effects of mycotoxins on the pig intestine
3. Consequences of intestinal toxicity of mycotoxins for pig health
Conclusion
References
B. Impact of mycotoxin on immune response and consequences for pig health (Review n°2)
Introduction
1. Effect of major mycotoxins on the pig immune response
2. Consequences of mycotoxin induced immunomodulation for pig health
3. The problem of mycotoxins co-contamination
Conclusion
References
C. Masked mycotoxins: a risk in pig production? (Review n°3)
Original Version (French)
English Version
Introduction
1. The mycotoxins regulated in pig’s feed
2. ”Modified” mycotoxins in pig feed
3. Assessment of the exposure and characterization of the risk for the “modified” mycotoxins in
pig
Conclusion
References
AIMS OF THE THESIS
EXPERIMENTAL STUDIES
I. Toxicity assessment of derivatives of deoxynivalenol (DON)
A. Intestinal toxicity of the masked mycotoxin deoxynivalenol-3 -glucoside (Article n°1)
Introduction
Materials and Method
Results
Discussion
References
B. Microbial biotransformation of DON: molecular basis for reduced toxicity (Article n°2)
Introduction
Materials and Methods
Results
Discussion
References
II. In vivo toxicity of purified deepoxy-deoxynivalenol (DOM-1) in piglets (Article n°3)
Introduction
Materials and Method
Results
Discussion
References
GENERAL DISCUSSION & PERSPECTIVES
I. Discussion
A. Discussion on the analysis performed in the thesis
1. In silico analysis of the interaction between DON, DON derivatives and the ribosome
2. Pan genomic analysis of the effect of DON and its derivatives
3. The in vivo experimental protocol
B. Toxicity assessment of biological strategies to reduce toxic effects of DON
1. Efficiency of detoxifying strategies
a) Bacterial transformation
b) Plant transformation
II.Perspectives
CONCLUSION