Natural course of Multiple Sclerosis (MS)

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Table of contents

INTRODUCTION
I. Myelin, nodes of Ranvier and the myelination process
a) Composition and organization of myelinated fibers
b) Functional properties of myelin and nodes of Ranvier
c) Myelination process and adaptive myelination
i. Oligodendrocyte lineage and myelin
ii. Formation of Nodes of Ranvier
II. Demyelination and remyelination processes in Multiple Sclerosis and its experimental models
a) Natural course of Multiple Sclerosis
b) Demyelination in MS
c) Remyelination
i. Remyelination in experimental models
ii. Remyelination in MS
d) Nodes of Ranvier in demyelination and remyelination
i. Nodes of Ranvier fate during demyelination
ii. Nodes of Ranvier assembly in remyelination
iii. Consequence of Nodes of Ranvier alterations on neuronal physiology
iv. Nodes of Ranvier and glial cells (Fig.16)
III. Microglia: a new major player in MS
a) Description and function of microglial cells
b) Classification of microglia phenotypes in health and disease
c) A dynamic and social cell
d) Microglia and Multiple Sclerosis: a dual role.
i. A role in inflammation
ii. Microglial role in repair
GENERAL DISCUSSION
I. Characteristics of node-microglia interaction in control tissue
II. Characteristics of node-microglia interaction in pathological states
III. Node-microglia interaction could participate in the microglial switch in repair
IV. Microglial profiles observed in human tissues
V. Nodes of Ranvier as a glial-communication hub
CONCLUSION