Neurobiological substrates of aversion

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Table of contents

INTRODUCTION
THE CIRCUITS OF MOTIVATION – IS IT ALL ABOUT DOPAMINE?
NEUROBIOLOGICAL SUBSTRATES OF AVERSION
THE LATERAL HABENULA: A CONTROL STATION OF AVERSION
PHYLOGENY AND ANATOMY OF THE LHB
INPUTS TO THE LHB
OUTPUT CONNECTIVITY OF THE LHB
FUNCTION OF THE LHB IN REWARD AND AVERSION ENCODING
ROLE OF LHB OUTPUT FOR AVERSION PROCESSING
ROLE OF INPUTS TO THE LHB FOR AVERSION PROCESSING
DYSFUNCTION OF THE LHB: IMPLICATIONS IN DEPRESSION AND ADDICTION
LHB IN DEPRESSION
LHB IN ADDICTION
PROPERTIES OF LATERAL HABENULA NEURONS
CELL MORPHOLOGY AND ELECTROPHYSIOLOGY
FAST EXCITATORY TRANSMISSION VIA IONOTROPIC GLUTAMATE RECEPTORS
FAST INHIBITORY SYNAPTIC TRANSMISSION VIA IONOTROPIC GABAA RECEPTORS
MODULATION OF FAST EXCITATORY AND INHIBITORY TRANSMISSION: ROLE OF MGLURS
SYNAPTIC PLASTICITY IN THE LHB: A CELLULAR SUBSTRATE FOR MOTIVATED STATES IN
DISEASE
CELLULAR MECHANISMS IN THE LHB IN DEPRESSION
CELLULAR MECHANISMS IN THE LHB IN ADDICTION
CONTEXT AND OBJECTIVES FOR THE STUDIES
I. MGLUR-LTD AT EXCITATORY AND INHIBITORY SYNAPSES CONTROLS LATERAL HABENULA OUTPUT
II. COCAINE-EVOKED NEGATIVE SYMPTOMS REQUIRE AMPA RECEPTOR TRAFFICKING IN THE LATERAL HABENULA
DISCUSSION
WHICH INPUTS UNDERGO MGLUR-ELTD AND ILTD?
IS THERE ANY OUTPUT-SPECIFICITY FOR MGLUR-ELTD AND ILTD?
WHAT IS THE BEHAVIORAL RELEVANCE OF MGLUR-LTD IN THE LHB?
INDUCTION MECHANISMS AND CIRCUIT SPECIFICITY OF COCAINE-EVOKED PLASTICITY IN THE LHB
SYNAPTIC ADAPTATIONS AFTER COCAINE WITHDRAWAL
DISTINCT SYNAPTIC ADAPTATIONS CONVERGE TO INCREASE LHB NEURONAL AND BEHAVIORAL OUTPUT
CONCLUDING REMARKS
ADDITIONAL PUBLICATIONS AND CONTRIBUTIONS
REFERENCE LIST