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Table of contents
Foreword
Table of illustrations
List of abbreviations
1 Introduction
1.1 Cerebellum
1.1.1 Anatomical architecture and main connections
1.1.2 Cellular organization of the cerebellum
1.1.3 Postnatal development of the cerebellar cortex
1.2 Cerebellar functions
1.3 Actors of the glutamatergic transmission in Purkinje cells
1.3.1 Glutamate receptors of Purkinje cells
1.3.2 Glutamate Transporters
1.3.3 Excitatory responses evoked in Purkinje cells by its glutamatergic afferents
1.4 NMDA-receptors in Purkinje cells
1.4.1 NMDA-R: general properties
1.4.2 Purkinje cells express NR1 subunits throughout the postnatal and adult life
1.4.3 NMDA-Rs of Purkinje cells in neonatal rodents (first postnatal week)
1.4.4 Second postnatal week: a gap in the expression of NMDA-Rs
1.4.5 NMDA-Rs of the adult Purkinje cells: a controversy
1.5 Problem and work hypothesis
2 Materials and methods
2.1 Animals
2.2 Slice preparation
2.3 Electrophysiology
2.4 Solutions and pharmacology
2.5 Data analysis and inclusion criteria
2.6 Immunohistochemistry
3 Results
3.1 Publication 1: Neuroprotective effect of mifepristone involves neuron depolarization
3.1.1 Introduction
3.1.2 Summary of the results
3.1.3 Discussion
3.2 Publication 2: NMDA receptor contribution to the climbing fiber response in the adult mouse Purkinje cell
3.2.1 Introduction
3.2.2 Summary of experimental results
3.2.3 Discussion
3.3 Manuscript to submit: NMDA receptor participation to climbing fiber EPSC in adult mouse Purkinje cells lacking the delta2- glutamate receptor
3.3.1 Introduction and summary
3.3.2 Manuscript
3.3.3 Discussion in the context of the present thesis
3.4 Results in progress: NMDA receptor involvement in bidirectional plasticity of parallel fiber to Purkinje cells synapses
3.4.1 Introduction
3.4.2 Preliminary results
3.4.3 Discussion
4 Summary and conclusions
References
