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Table of contents
Chapter 1: Literature Review on gut-derived peptides and their mechanism of action on vagal afferent neurons
1.1 Introduction
1.2 Nutrient sensing in the GI tract
1.2.1 Recent advances in understanding nutrient sensing
1.3 Importance of gut-derived hormones on regulation of food intake
1.3.1 Glucagon like peptide-1
1.3.2 Ghrelin
1.3.3 Leptin
1.3.4 Cholecystokinin
1.4 The Vagus Nerve
1.4.1 Phenotypic Changes of VAN According to Feeding Status
1.4.2 VAN phenotype in diet induced obesity
1.4.3 Summary
1.5 GLP-1 secretion in the GI tract
1.6 The insulinotropic activity of GLP-1
1.7 GLP-1 and the control of food intake
1.7.1 Evidence that Ghrelin Modulates GLP-1-induced Actions
1.7.2 Evidence that Leptin Interacts with GLP-1 actions
1.7.3 Summary
1.8 The role of leptin in obesity
1.8.1 Summary
1.9 Sex differences influence energy homeostasis
1.10 Conclusion
1.11 Objectives of Dissertation
1.12 References
Chapter 2: Experimental Chapter on investigating the mechanism of action of gut-derived peptides on vagal afferent neurons
2.1: Ability of Glucagon like Peptide-1 to Decrease Food Intake is Dependent on Nutritional Status
2.1.1 Abstract
2.1.2 Highlights
2.1.3 Introduction
2.1.4 Methods
2.1.5 Results
2.1.6 Discussion
2.1.7 References
.2: Ghrelin inhibits translocation of Glucagon like Peptide-1 Receptors to the plasma membrane of vagal afferent neurons
2.2.1 Abstract
2.2.2 Highlights
2.2.3 Introduction
2.2.4 Methods
2.2.5 Results
2.2.6 Discussion
2.2.7 References
3: Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity
2.3.1 Abstract
2.3.2 Highlights
2.3.3 Introduction
2.3.4 Methods
2.3.5 Results
2.3.6 Discussion
2.3.7 References
4: Knockdown of Leptin Receptor on vagal afferent neurons drives obesity differently in female than male mice
2.4.1 Abstract
2.4.2 Highlights
2.4.3 Introduction
2.4.4 Methods
2.4.5 Results
2.4.6 Discussion
2.4.7 References
Chapter 3: Discussion and Conclusion
3.1 Introduction
3.2 Objectives and aims
3.3 Summary of findings
3.4 Main findings
3.5 Limitations
3.6 Possible future research
3.7 Conclusion
3.8 References
