Short-Term Synaptic Plasticity

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Table of contents

ACKNOWLEDGEMENTS
INDEX
LIST OF FIGURES AND TABLES
LIST OF ABBREVIATIONS
SUMMARY
ABSTRACT
RÉSUMÉ
INTRODUCTION
PART 1: SYNAPTIC DEVELOPMENT NEVER STOPS
1. The Formation and Maturation of Excitatory Synapses
2. Synaptic Plasticity
2.1. Short-Term Synaptic Plasticity
2.2. Long-Term Synaptic Plasticity
3. AMPA-type Receptor Turnover
3.1. AMPA-type Receptors
3.2. AMPA-type Receptor Turnover
3.2.1. Delivery of AMPARs to the Synapse
3.2.2. AMPARs Membrane Insertion
3.2.3. Surface AMPARs: Stabilization, Anchoring and Clustering
3.2.4. Lateral Diffusion of AMPARs
3.2.5. Endocytosis of the AMPAR: Internalization
3.2.6. AMPARs Recycling
3.2.7. Degradation of AMPARs
3.2.8. Colophon
PART 2: THE OLIVOCEREBELLAR NETWORK AS A MODEL TO STUDY EXCITATORY SYNAPSE FORMATION AND FUNCTION
1. Organization of the Olivocerebellar Network
1.1. Global Structure of the Cerebellum and Inferior Olive
1.2. Histology of the Cerebellar Cortex
1.3. Cerebellar Efferences and Afferences
1.4. Afferences and Efferences of the Inferior Olive
2. The Life of Purkinje Cell Excitatory Synapses
2.1. The Parallel Fiber/Purkinje Cell Synapse
2.2. The Climbing Fiber/Purkinje Cell Synapse
3. Cerebellar Functions
3.1. Sensorimotor Cerebellar Functions
3.2. Cognitive Cerebellar Functions
PART 3: SUSHI DOMAIN PROTEINS IN THE NERVOUS SYSTEM
1. The Sushi Domain
2. Sushi Domain-containing Proteins are Evolutionarily Conserved in the Nervous System
2.1. Caenorhabditis elegans: LEV-9
2.2. Drosophila melanogaster: Hig and Hasp
2.3. Vertebrata
2.3.1. GABAB Receptors
2.3.2. SEZ-6
2.3.3. SRPX2
2.3.4. SUSD Family
2.3.5. CSMD Family
RESULTS
PREFACE
PART 1: ROLE OF THE SUSHI DOMAIN PROTEIN SUSD4 IN THE BRAIN
1. Article in Preparation
2. Effect of SUSD4 on Transmission and GluA2 Content in Climbing Fiber Synapses Changes with Maturation
3. Susd4 Deletion Leads to a Defect on a Hippocampal-dependent Behavioral Task
4. Materials and Methods
PART 2: MASP1/3 IS EXPRESSED IN THE OLIVOCEREBELLAR SYSTEM
1. Introduction
2. Results
3. Discussion
4. Perspectives
5. Experimental Procedures
6. References
DISCUSSION
1. Sushi Domains in the Nervous System
2. SUSD4 Controls Activity-dependent AMPAR Degradation
3. Conclusion and Future Directions.
ANNEXUS
ANNEXE 1: THE SECRETED PROTEIN C1QL1 AND ITS RECEPTOR BAI3 CONTROL THE SYNAPTIC CONNECTIVITY OF EXCITATORY INPUTS CONVERGING ON CEREBELLAR PURKINJE CELLS
ANNEXE 2: EXPRESSION AND ROLE OF GALECTIN-3 IN THE POSTNATAL DEVELOPMENT OF THE CEREBELLUM
BIBLIOGRAPHY