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Table of contents
I. INTRODUCTION
I.1. The heart
I.2. Myocardial infarction
I.2.1 Pathophysiology
I.2.2 Reperfusion injury
2.1. Myocardial stunning
I.2.2.2. No No-reflow phenomenon
I.2.3 Infarct healing
Post-infarction left ventricular remodeling
I.3.1. Mechanisms
I.3.2. Temporal evolution
I.3.3. Clinical importance
I.4. Utilization of cardiac MRI in post post-MI LV remodeling
I.4.1. Basic concepts of cardiac MRI
I.4.1.1. T1 and T2 relaxation
I.4.1.2. Synchronization in cardiac MRI
I.4.1.3. Cardiac imaging planes and LV segmentation model
I.4.2. Common cardiac MRI sequences used in myocardial infarction
I.4.2.1. Cine MRI
I.4.2.2. T2-weighted imaging, T2WIweighted imaging, T2WI
I.4.2.3. Late gadolinium-enhancement, LGEenhancement, LGE
I.4.3. Cardiac MRI findings and prognostic significance
I.4.3.1. Prognostic significance of infarct sizerct size
I.4.3.2. Infarct shrinkage
I.4.3.3. Infarct heterogeneity
I.4.3.4. No-reflow or microvascular obstruction, MVOreflow or microvascular obstruction, MVO
I.5. Synopsis of REMI study
I.5.1. Objectives
I.5.2. Patient inclusion
I.5.3. Exams conducted
I.5.3.1. Blood tests
I.5.3.2. Echocardiography
I.5.3.3. Cardiac MRI
II. Work accomplished
II.1. Standardization of methods for LGE quantification
II.2. Quantitative characterization of LGE region
II.3. Cardiac MRI predictors for LV remodeling
II.4. Impact of MVO on LV wall and local remodeling
III. Overall conclusion and perspectives
References
