The development of serotonin neurons in raphe nuclei

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Table of contents

Part 1: Serotonin raphe neurons and topographic mapping of serotonergic projections
1. History
2. Biochemistry of serotonin system
3. Serotonin neuroanatomy – Anatomical organization of the raphe nuclei and serotonergic raphe neurons
4. The development of serotonin neurons in raphe nuclei
Part 2: Molecular pathway of serotonin system and Eph family
1. From growth cone to axon guidance
2. Molecular mechanism of serotonin raphe neuronal wiring.
3. Eph receptors and their ligands ephrins
4. Eph/ephrin signaling mechanisms
5. EphA5 and ephrinA5 from past to present
6. The mechanism of EphA5 modulated growth cone collapse
7. The role of EphA5-ephrinA5 interaction within the hypothalamus from glutamine system to aggressive behavior
Results
Part 1: EphAs-EphrinAs signaling is required for the distinctive targeting of raphe 5-HT neurons in the telencephalon
Part 2: Study of serotonin raphe neurons projections during development with an IDISCO method 
Discussion
Bibliography