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Table of contents
Introduction
I. Biomaterials for tissue regeneration
1. The extracellular matrix
2. Biomaterials to mimic the ECM
3. Bionanocomposites for tissue regeneration
4. References
II. Influence of the bio-chemical signal clusterization on cell adhesion in a Peptide Amphiphile – SiNP composite
1. Introduction to Peptide Amphiphiles
2. Chemical Design
3. Preparation and characterization of the composite
4. Biological activity
5. Conclusion
6. Experimental methods
7. References
III. Nanostructuration of 3D surfaces: Clusterization on silica nanoparticles
1. Introduction to Patchy Particles
2. Synthesis of self-assembling silanes bearing an aromatic moiety
3. Self-assembly of the synthesized alkoxysilanes
4. Transfer of An self-assemblies to the SiNP surface to create Patchy SiNPs
5. Bifunctional patchy particles
6. Conclusion and perspectives
7. Experimental section
8. References
IV. Biomaterials engineering for neural type cells differentiation
1. Peripheral nerve regeneration
2. Engineering a bionanocomposite
3. Bionanocomposites of the study
4. PC12 differentiation on collagen-SiNP threads
5. Discussion
6. Conclusion and perspectives
7. Experimental methods
8. References
V. Self-supported collagen-based matrices by electrospinning
1. Electrospinning
2. A self-supported membrane
3. Investigating the native structure of collagen by circular dichroism (CD)
4. Characterizing the collagen structure within the membrane
5. Cell adhesion on the different matrices
6. Conclusion and perspectives
7. Experimental methods
8. References
Conclusion
Appendix
I. Patchy Particles by grafting Py precursor
II. Conjugation of di-mercaptosuccinic- acid modified Fe2O3 particles
III. Synchrotron-radiation Oriented Linear Dichroism of collagen
List of abbreviations

