Trivalent arsenic and T cells

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Table of contents

1. Introduction
1.1. Immunomodulatory properties of trivalent arsenic
1.1.1. Pharmaceutical mechanisms of action
1.1.2. The multifaceted effects of trivalent arsenic on immune cells
1.1.3. Trivalent arsenic in mouse models of immune-mediate diseases
1.1.4. Trivalent arsenic and tumor immunotherapy
1.2. Plasmacytoid dendritic cells in autoimmunity/alloreactivity
1.2.1. Definition of pDCs
1.2.2. Development of pDCs
1.2.3. Functions of pDCs
1.2.4. pDCs in autoimmunity
1.2.5. pDCs in alloreactivity
1.3. Mouse models of acute GVHD
1.3.1. Acute GVHD (aGVHD)
1.3.2. Challenges in aGVHD prophylaxis/treatment
1.3.3. Translational value of existing aGVHD mouse models
2. Results
2.1. Part 1. Immunomodulatory effects of arsenic trioxide on plasmacytoid dendritic cells and study of mechanism
2.1.1. Article 1: Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon-alpha inhibition
2.2. Part 2. Effects of arsenic trioxide and other immunomodulatory drugs in a novel mouse models of acute graft-versus-host disease
2.2.1. Results
2.2.2. Materials and Methods
3. Discussions
3.1. As2O3, a promising drug for diseases with IFN-I signature
3.2. A novel aGVHD model with chemotherapy-based conditioning and G-CSF mobilized graft: advances and limitations
4. Conclusion
5. References
6. Annex