Wiring the developing CNS

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Table of contents

CHAPTER I: COMPREHENSIVE REVIEW OF THE LITERATURE
I.1. The unique embryonic origin of microglia
I.1.1. Ontogeny of microglia
I.1.2. Development of microglia
I.2. The role of microglia in CNS development
I.2.1. Patterning the developing CNS
I.2.2. Wiring the developing CNS
I.3. The role of microglia in the mature CNS
I.3.1. Regulating mature CNS circuits
I.3.2. Surveilling the CNS
I.3.3. Mediating CNS immune response
I.4. Heterogeneity of microglia
I.4.1. Heterogeneity of microglia throughout the brain
I.4.2. Heterogeneity of microglia across sex
I.5. Maternal Immune Activation & neurodevelopmental disorders
I.6. Maternal Immune Activation & microglia
I.6.1. Effects of Maternal Immune Activation on embryonic microglia
I.6.2. Effects of Maternal Immune Activation on postnatal microglia
I.7. Hypothesis
I.8. Objectives
C. Lacabanne – PhD thesis Table of contents
CHAPTER II: HIPPOCAMPAL MICROGLIA DEPLETION IMPROVES LPS-INDUCED DEPRESSIVE-LIKE BEHAVIOUR AND IDO EXPRESSION
II.1. Manuscript
Abstract
Introduction
Materials and Methods
Results
Discussion
Acknowledgement
Figures
Reference List
CHAPTER III: EARLY MATERNAL IMMUNE ACTIVATION ALTERS MICROGLIA DEVELOPMENTAL TRAJECTORY AND INDUCES LONG-TERM BEHAVIOURAL ALTERATIONS IN THE OFFSPRING IN A SEXUALLY DIMORPHIC MANNER 
III.1. Preface
III.2. Manuscript
Abstract
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
Figures
Reference List
CHAPTER IV: INTERLEUKIN-1 MEDIATES THE EFFECTS OF PRENATAL LPS INDUCED BEHAVIOURAL ANOMALIES IN THE OFFSPRING THROUGH MODULATING MICROGLIA
IV.1. Preface
IV.2. Manuscript
Abstract
Introduction
Materials and Methods
Results
C. Lacabanne – PhD thesis Table of contents
Discussion
Acknowledgements
Figures and Tables
Reference List
GENERAL DISCUSSION AND CONCLUSION
BIBLIOGRAPHY